Research Center for High Performance Sport. University of Murcia, Campus de los Jerónimos, Guadalupe 30107, Murcia, Spain.
Health, Economy, Motricity and Education Research Group (HEME), Faculty of Sport Sciences, University of Extremadura, Avda. de la Universidad, s/n., 10003 (Cáceres), Spain.
Food Funct. 2021 May 11;12(9):3872-3882. doi: 10.1039/d0fo03456h.
2S-Hesperidin is the main flavonoid of orange (Citrus sinensis). Previous researches have pointed its effects in muscle development and fat accumulation reduction, although most of these results have not been assessed in humans. The objective of this study is to evaluate the effect of chronic (8-weeks) intake of 2S-hesperidin on amateur cyclists' body composition. A double-blind, parallel and randomized trial, was carried out with 40 amateur cyclists that were divided in two groups, one taking 2S-hesperidin (500 mg d-1, n = 20) and another taking placebo (500 mg d-1 microcellulose, n = 20) for 8 weeks. Dual-energy X-ray absorptiometry (DXA) and anthropometric measurements were used to assess the effect of both treatments on body composition. In addition, the resting metabolic rate was measured. In comparison to placebo, DXA analysis showed a decrease in percentage body fat (%BF) (-10.4%; p = 0.035) and lower limb fat mass (-10.5%; p = 0.029) in favour of 2S-hesperidin. After evaluation of anthropometric data, a decrease in %BF (-3.7%; p = 0.006), total body fat (-3.0%; p = 0.047), ∑ of 8 skinfolds (-6.1%; p = 0.008) was observed in 2S-hesperidin group, but not in placebo. Additionally, there was an increase in muscle mass percentage (1.0%; p = <0.001) and total muscle mass (1.7%; p = 0.011) after ingestion of 2S-hesperidin, with no changes in placebo. Chronic intake of 2S-hesperidin decreased fat mass in amateur cyclists, evaluated through different body composition measurement methodologies (DXA and anthropometry). In addition, 2S-hesperidin supplementation showed a promoting effect on muscle development.
2S-柚皮苷是橙子（Citrus sinensis）的主要类黄酮。以前的研究指出它在肌肉发育和减少脂肪积累方面的作用，尽管这些结果大多数尚未在人体中得到评估。本研究的目的是评估慢性（8 周）摄入 2S-柚皮苷对业余自行车运动员身体成分的影响。进行了一项双盲、平行和随机试验，共纳入 40 名业余自行车运动员，分为两组，一组服用 2S-柚皮苷（500mg/d，n=20），另一组服用安慰剂（500mg/d 微晶纤维素，n=20），为期 8 周。使用双能 X 射线吸收法（DXA）和人体测量学测量来评估两种治疗方法对身体成分的影响。此外，还测量了静息代谢率。与安慰剂相比，DXA 分析显示 2S-柚皮苷组体脂百分比（%BF）下降（-10.4%；p=0.035）和下肢脂肪量下降（-10.5%；p=0.029）。在评估人体测量数据后，2S-柚皮苷组观察到 %BF 下降（-3.7%；p=0.006）、总体脂肪下降（-3.0%；p=0.047）、8 个皮褶总和下降（-6.1%；p=0.008），但安慰剂组没有。此外，2S-柚皮苷组肌肉质量百分比增加（1.0%；p<0.001）和总肌肉质量增加（1.7%；p=0.011），而安慰剂组没有变化。慢性摄入 2S-柚皮苷可减少业余自行车运动员的脂肪量，通过不同的身体成分测量方法（DXA 和人体测量学）进行评估。此外，2S-柚皮苷补充剂对肌肉发育有促进作用。
