用于基于酶的即时检测肌酐的纳米集成微流控生物芯片。
A nano-integrated microfluidic biochip for enzyme-based point-of-care detection of creatinine.
机构信息
Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China.
State Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.
出版信息
Chem Commun (Camb). 2021 May 11;57(38):4726-4729. doi: 10.1039/d1cc00825k.
A nano-integrated portable enzymatic microfluidic electrochemical biochip was developed for single-step point-of-care testing of creatinine. The biochip could automatically eliminate a lot of interferences from practical biological samples and enzymatic intermediate products. Gold nanostructure- and carbon nanotube-based screen-printed carbon electrodes were integrated into microfluidic structures to improve the detection performance for creatinine. The microfluidic electrochemical biochip holds promise to become a practical device for medical diagnosis, especially POCT.
一种纳米集成式便携式酶微流控电化学生物芯片被开发出来，用于肌酐的一步式即时检测。该生物芯片可以自动消除实际生物样本和酶中间产物的许多干扰。基于金纳米结构和碳纳米管的丝网印刷碳电极被集成到微流控结构中，以提高对肌酐的检测性能。该微流控电化学生物芯片有望成为一种实用的医疗诊断设备，特别是在即时检测方面。
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