Associate Professor. Universidade Federal de Minas Gerais - Medical School - Department of Surgery - Belo Horizonte (MG), Brazil.
Associate Professor. Universidade Federal de Minas Gerais - Medical School - Department of Propedeutics - Belo Horizonte (MG), Brazil.
Acta Cir Bras. 2021 May 7;36(4):e360402. doi: 10.1590/ACB360402. eCollection 2021.
To assess the influence of prolonged cyclosporine use on the macro- and microscopic morphology of the spleen.
16 adult rabbits were divided into two groups (n = 8): group 1 - a placebo group, which was followed-up over a period of nine months; group 2 - which had taken an oral dose of cyclosporine (10 mg·kg-1·day-1) over nine months. At the end of this period, the splenic histoarchitecture of all animals was evaluated and the splenic corpuscles were measured.
The spleens of the first group presented normal characteristics and dimensions. The second group, however, had a reduction in all dimensions and its tissue texture had become soft. The white pulp and the perivascular sheath had become reduced in size and the number of lymphoid follicles had also fallen (p = 0.002), manifesting less splenic corpuscles (p = 0.0012) and lymphocyte nuclear pigments (p = 0.03).
Prolonged use of cyclosporine reduces the spleen size, transforming it into a soft organ associated with a decrease in white pulp, perivascular sheath, lymphoid follicles and nuclear pigments in rabbits.
评估环孢素长期使用对脾脏宏观和微观形态的影响。
将 16 只成年兔分为两组（n = 8）：第 1 组为安慰剂组，随访 9 个月；第 2 组给予环孢素（10mg·kg-1·天-1）口服 9 个月。在此期间结束时，评估所有动物的脾组织形态并测量脾小体。
第 1 组的脾脏呈现正常特征和尺寸。然而，第 2 组的所有尺寸均减小，组织质地变软。白髓和血管周围鞘变小，淋巴滤泡数量减少（p = 0.002），脾小体（p = 0.0012）和淋巴细胞核色素（p = 0.03）也减少。
环孢素的长期使用会导致兔子的脾脏缩小，质地变软，与白髓、血管周围鞘、淋巴滤泡和核色素减少有关。
