Stankiewicz M, Sobiczewska E, Jeska E L
Department of Immunology, Institute of Zoology, Warszawa, Poland.
J Parasitol. 1988 Aug;74(4):713-4.
Trichinella spiralis infections provoke a variety of responses in the host, some of which involve stem cell proliferation and myeloid cell maturation, increases in the mast cell precursor cell populations, and maturation and eosinopoiesis. Very little is known about the influence of T. spiralis upon bone marrow stem cells and splenic colony formation. In the present communication we report that T. spiralis infection in mice stimulates the generation of colony-forming units in the spleen (CFU-S). Passive transfer of bone marrow cells from uninfected BALB/c mice to X-irradiated (650 R) T. spiralis-infected recipients resulted in a significant increase of CFU-S at 14 and 24 days postinfection. Passive transfer of bone marrow cells from T. spiralis-infected mice to X-irradiated uninfected mice also resulted in increased numbers of CFU-S in the donor mice at 24 days postinfection. These findings strongly suggest that T. spiralis infection conditions the microenvironment in the spleen which stimulates CFU-S.
旋毛虫感染会在宿主体内引发多种反应，其中一些反应涉及干细胞增殖和髓样细胞成熟、肥大细胞前体细胞群体增加以及成熟和嗜酸性粒细胞生成。关于旋毛虫对骨髓干细胞和脾集落形成的影响，人们了解甚少。在本报告中，我们指出小鼠感染旋毛虫会刺激脾集落形成单位（CFU-S）的生成。将未感染的BALB/c小鼠的骨髓细胞被动转移到经X射线照射（650伦琴）的旋毛虫感染受体小鼠体内，在感染后14天和24天时，CFU-S显著增加。将旋毛虫感染小鼠的骨髓细胞被动转移到经X射线照射的未感染小鼠体内，在感染后24天时，供体小鼠体内的CFU-S数量也增加了。这些发现有力地表明，旋毛虫感染会调节脾脏中的微环境，从而刺激CFU-S。
