Structurally Diverse Diterpenoids from the Roots of Based on Nine Different Skeletal Types.

Twenty-four diterpenoids (-), classified into nine diverse carbon skeletal types, 8--7(8→14),9(8→7)-di--abietane (, , and ), 7(8→14),9(8→7)-di--abietane ( and ), 6--6,7--abietane ( and ), 6,7--abietane ( and ), 9,10--abietane (), abietane (, , and -), 11(9→8),20(10→11)-di--abietane (), 15(13→12)--abietane ( and ), and 4,5--20(10→5)--abietane (), respectively, were isolated from the roots of . The structures of 10 new diterpenoids, named salviadesertins A-J (-), were elucidated by spectroscopic data interpretation, quantum-chemical calculations including calculated C NMR-DP4+ analysis and electronic circular dichroism as well as X-ray crystallography analysis. The absolute configurations of compounds -, , , and were defined by single-crystal X-ray diffraction analysis. All the isolated diterpenoids - were evaluated for their cytotoxicity against five cancer cell lines, and 6-hydroxysalvinolone () showed micromolar potencies against MCF-7, A-549, SMMC-7721, and HL-60 cells, whereas the other diterpenoids were inactive (half-maximal inhibitory concentration greater than 10.0 μM).