Kadir Abdukriem, Zheng Guijuan, Zheng Xiaofeng, Jin Pengfei, Maiwulanjiang Maitinuer, Gao Biao, Aisa Haji Akber, Yao Guangmin
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, People's Republic of China.
J Nat Prod. 2021 May 28;84(5):1442-1452. doi: 10.1021/acs.jnatprod.0c01180. Epub 2021 May 12.
Twenty-four diterpenoids (-), classified into nine diverse carbon skeletal types, 8--7(8→14),9(8→7)-di--abietane (, , and ), 7(8→14),9(8→7)-di--abietane ( and ), 6--6,7--abietane ( and ), 6,7--abietane ( and ), 9,10--abietane (), abietane (, , and -), 11(9→8),20(10→11)-di--abietane (), 15(13→12)--abietane ( and ), and 4,5--20(10→5)--abietane (), respectively, were isolated from the roots of . The structures of 10 new diterpenoids, named salviadesertins A-J (-), were elucidated by spectroscopic data interpretation, quantum-chemical calculations including calculated C NMR-DP4+ analysis and electronic circular dichroism as well as X-ray crystallography analysis. The absolute configurations of compounds -, , , and were defined by single-crystal X-ray diffraction analysis. All the isolated diterpenoids - were evaluated for their cytotoxicity against five cancer cell lines, and 6-hydroxysalvinolone () showed micromolar potencies against MCF-7, A-549, SMMC-7721, and HL-60 cells, whereas the other diterpenoids were inactive (half-maximal inhibitory concentration greater than 10.0 μM).
从[植物名称]的根部分离出了24种二萜类化合物（-），它们被分为九种不同的碳骨架类型，分别是8 - 7(8→14),9(8→7)-二 - 松香烷（[化合物1]、[化合物2]和[化合物3]）、7(8→14),9(8→7)-二 - 松香烷（[化合物4]和[化合物5]）、6 - [取代基1]-6,7 - [取代基2]-松香烷（[化合物6]和[化合物7]）、6,7 - [取代基3]-松香烷（[化合物8]和[化合物9]）、9,10 - [取代基4]-松香烷（[化合物10]）、松香烷（[化合物11]、[化合物12]和[化合物13]-[化合物14]）、11(9→8),20(10→11)-二 - 松香烷（[化合物15]）、15(13→12)-[取代基5]-松香烷（[化合物16]和[化合物17]）以及4,5 - [取代基6]-20(10→5)-[取代基7]-松香烷（[化合物18]）。通过光谱数据解析、包括计算碳核磁共振 - DP4 + 分析和电子圆二色性的量子化学计算以及X射线晶体学分析，阐明了10种新的二萜类化合物的结构，它们被命名为丹参沙漠素A - J（-）。化合物[化合物19] - [化合物22]的绝对构型通过单晶X射线衍射分析确定。对所有分离得到的二萜类化合物[化合物1] - [化合物24]进行了针对五种癌细胞系的细胞毒性评估，6 - 羟基丹参酮（[化合物23]）对MCF - 7、A - 549、SMMC - 7721和HL - 60细胞显示出微摩尔级别的活性，而其他二萜类化合物则无活性（半数最大抑制浓度大于10.0 μM）。
