从西南卫矛根中分离得到的新松香烷型二萜及其对人癌细胞的细胞毒性
New abietane-type diterpenoids from roots of Euonymus hamiltonianus and their cytotoxicity in human cancer cell.
作者信息
Huh Jungmoo, Park Eun Jin, Lee Jae Hyun, Park Chan-Woong, Yang Tae-Jin, Oh Won Keun, Chin Young-Won
机构信息
Natural Product Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
出版信息
J Nat Med. 2025 May;79(3):666-672. doi: 10.1007/s11418-025-01887-6. Epub 2025 Mar 1.
Two new abietane-type diterpenoids, 6β-(3-furoyloxy)ferruginol (1) and 6-chloro-6,7-dehydroferruginol (2), were isolated from the roots of Euonymus hamiltonianus along with five known diterpenoids (3-7). Their structures were characterized using various spectroscopic analysis including HRMS, 1D and 2D NMR, and ECD analysis. All isolated compounds (1-7) were evaluated for their cytotoxic activity against human colon cancer cell line, HCT116, and it was found to exhibit moderate cytotoxic activity with IC values ranging from 4.5 to 22.9 μM. Among the isolated compounds, montbretol (4) displayed the most cytotoxic activity (IC = 4.50 ± 0.29 μM) against HCT116 human colon cancer cells than the other isolated compounds.
从西南卫矛根部分离得到两个新的枞酸型二萜类化合物，6β-(3-呋喃甲酰氧基)铁锈醇(1)和6-氯-6,7-脱氢铁锈醇(2)，以及五个已知的二萜类化合物(3 - 7)。通过高分辨质谱(HRMS)、一维和二维核磁共振(1D和2D NMR)以及电子圆二色谱(ECD)分析等多种光谱分析方法对其结构进行了表征。对所有分离得到的化合物(1 - 7)进行了针对人结肠癌细胞系HCT116的细胞毒性活性评估，发现它们表现出中等细胞毒性活性，IC值范围为4.5至22.9 μM。在分离得到的化合物中，蒙布醇(4)对HCT116人结肠癌细胞的细胞毒性活性(IC = 4.50±0.29 μM)比其他分离得到的化合物更强。
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