Conti Nibali S, Barresi G, Tuccari G, Rivosecchi M, Magazzù G
Institute of Clinical Pediatrics, University of Messina, Italy.
J Pediatr Gastroenterol Nutr. 1988 Jul-Aug;7(4):602-7.
Data on the frequency of regression of Barrett's esophagus after medical therapy or antireflux surgery in adult patients are conflicting; these data, with regard to pediatric age, where Barrett's esophagus is considered rare, are scarce and disappointing after antireflux surgery. We report a 4-month-old infant affected by severe reflux esophagitis who developed a junctional-type Barrett's epithelium. Histochemical procedures to detect mucin pattern were also carried out. The regression of Barrett's esophagus was observed 4 months after antireflux surgery whereas medical therapy had been unsuccessful. We suggest that esophageal biopsy should also be performed in the presence of severe esophagitis. Longer follow-up observations of other patients may clarify the role of antireflux surgery when Barrett's esophagus complicates gastroesophageal reflux (GER).
关于成年患者接受药物治疗或抗反流手术后巴雷特食管消退频率的数据相互矛盾；而对于儿童患者，巴雷特食管被认为较为罕见，抗反流手术后相关数据稀缺且令人失望。我们报告了一名4个月大的婴儿，患有严重反流性食管炎，出现了交界型巴雷特上皮。还进行了检测粘蛋白模式的组织化学程序。抗反流手术后4个月观察到巴雷特食管消退，而药物治疗未成功。我们建议，在存在严重食管炎的情况下也应进行食管活检。对其他患者进行更长时间的随访观察，可能会阐明当巴雷特食管并发胃食管反流（GER）时抗反流手术的作用。
