Department of Psychology, University of Copenhagen, Copenhagen, Denmark; Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
Department of Psychology, University of Copenhagen, Copenhagen, Denmark; Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
J Affect Disord. 2021 Jun 15;289:125-134. doi: 10.1016/j.jad.2021.04.039. Epub 2021 Apr 27.
The International Society for Bipolar Disorders Targeting Cognition Task Force recommends the Screen for Cognitive Impairment in Psychiatry (SCIP) to screen for cognitive impairment in bipolar disorder. However, SCIP must be administered by a healthcare professional, which is often impossible due to time and resource constraints. Web-based, self-administered cognition screening tools may enable assessment and monitoring of patients' cognition at a much larger scale to a reduced cost. For this purpose, we developed the Internet-Based Cognitive Assessment Tool (ICAT) as a modified web-based version of SCIP. This study aimed to investigate the sensitivity and validity of ICAT for cognition assessment in bipolar disorder.
Thirty-five patients with bipolar disorder in full or partial remission and 35 healthy controls completed ICAT on a computer, the standard paper-and-pencil SCIP and a subjective cognition questionnaire and were rated for mood symptoms and functioning at the Copenhagen Affective Disorders Research Centre.
Patients displayed cognitive impairments compared to controls on the ICAT (t (61)=3.67, p<.001, d=0.93). There was a strong correlation between ICAT and SCIP Total Scores (r(61)=.72, p<.000) and moderate to strong correlations on subtest scores (r=.48-.63, ps<.001). Across all participants, lower ICAT scores correlated with more subjective cognitive complaints (r(59)=-.43, p<.001) and poorer psychosocial functioning (r(62)=-.47, p<.001).
ICAT is a sensitive and valid web-based tool for cognition assessment in patients with bipolar disorder. This highlights ICAT as a novel web-based cognition screening tool that is feasible for largescale assessment and monitoring of cognition in the clinical management of bipolar disorder.
国际双相障碍认知目标工作组建议使用精神科认知障碍筛查工具（SCIP）筛查双相障碍患者的认知障碍。然而，由于时间和资源的限制，SCIP 必须由医疗保健专业人员进行管理，这往往是不可能的。基于网络的自我管理认知筛查工具可以以更低的成本在更大的范围内评估和监测患者的认知能力。为此，我们开发了基于互联网的认知评估工具（ICAT），这是 SCIP 的一种基于网络的修改版。本研究旨在调查 ICAT 对双相障碍患者认知评估的敏感性和有效性。
35 名处于缓解期或部分缓解期的双相障碍患者和 35 名健康对照者在计算机上完成了 ICAT、标准纸笔版 SCIP 和主观认知问卷，并在哥本哈根情感障碍研究中心接受了情绪症状和功能评估。
与对照组相比，患者在 ICAT 上表现出认知障碍（t(61)=3.67，p<.001，d=0.93）。ICAT 总分与 SCIP 总分（r(61)=.72，p<.000）之间存在很强的相关性，而在子测试得分上则存在中度至高度的相关性（r=.48-.63，ps<.001）。在所有参与者中，ICAT 得分越低与更多的主观认知抱怨（r(59)=-.43，p<.001）和较差的社会心理功能（r(62)=-.47，p<.001）相关。
ICAT 是一种敏感且有效的用于评估双相障碍患者认知能力的基于网络的工具。这凸显了 ICAT 作为一种新颖的基于网络的认知筛查工具，在双相障碍的临床管理中，对于大规模评估和监测认知能力具有可行性。
