通过溶剂蒸发实现二苯丙氨酸晶体的分解与重新组装。

Disassembly and reassembly of diphenylalanine crystals through evaporation of solvent.

作者信息

Xia Jiarui, Sun Bingbing, Wang Chenlei, Sun Nan, Cao Hongqian, Jia Yi, Yang Yang, Li Junbai

机构信息

Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Science, Beijing 100049, China.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190 China; School of Public Health, Shandong University, Jinan 250000, China.

出版信息

J Colloid Interface Sci. 2021 Oct;599:661-666. doi: 10.1016/j.jcis.2021.04.062. Epub 2021 Apr 17.

DOI:10.1016/j.jcis.2021.04.062

PMID:33979748

Abstract

HYPOTHESIS

Crystalline self-assemblies of diphenylalanine (FF) are since long back considered to be related to Alzheimer's disease. An improved understanding of the mechanism behind the formation of such structures can lead to strategies for investigating the dynamic processes of assembly and disassembly of FF.

EXPERIMENT

The assembly, disassembly and reassembly of FF crystals are influenced by the solvent composition and can be triggered by evaporation of solvent. In this work these processes are directly monitored, and the structures obtained are analyzed.

FINDINGS

The role of the solvent for assembly, disassembly and reassembly of diphenylalanine crystals has been demonstrated. The initial crystal structure formed via self-assembly of FF monomers can be transformed into needle-like crystals and further to hollow hexagonal microtubes through evaporation of the solvent. It is shown that all the assembly-disassembly processes are spontaneous and driven by thermodynamics. It is also found that some of the crystalline structures exhibit optical waveguiding properties.

摘要