Centre clinical neuroplasticity Medical Park Loipl, Germany.
Technical University of Munich, Germany.
Mult Scler Relat Disord. 2021 Jul;52:102986. doi: 10.1016/j.msard.2021.102986. Epub 2021 Apr 28.
Quality of life (QOL) has been reported to be reduced in persons with multiple sclerosis. Further, associations between QOL and the clinical severity of the disease as well as sensorimotor function were shown. We reinvestigated impacting factors on QOL by the additional assessment of depression, fatigue, satisfaction with life, and a battery of end-effector based assessments of sensorimotor functioning. Models of multiple linear regression revealed everyday life activity limitations to be the driving factor within the used questionnaire and no association with sensorimotor tests, but depression, fatigue, and satisfaction with life. We conclude that either psycho-emotional coping and adaptability are the dominant determinant of QOL or that QOL is in need of a quantitative and objective reconceptualization.
生活质量（QOL）已被报道在多发性硬化症患者中降低。此外，生活质量与疾病的临床严重程度以及感觉运动功能之间存在关联。我们通过额外评估抑郁、疲劳、生活满意度以及一系列基于末端效应器的感觉运动功能评估，重新研究了影响生活质量的因素。多元线性回归模型显示，日常生活活动受限是使用问卷中的驱动因素，与感觉运动测试无关，但与抑郁、疲劳和生活满意度有关。我们得出结论，要么是心理情绪应对和适应能力是生活质量的主要决定因素，要么是生活质量需要进行定量和客观的重新概念化。
