The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, National Engineering Lab for Textile Fiber Materials and Processing Technology, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China.
Academy of Science and Technology, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China.
Biomed Mater. 2021 May 26;16(4). doi: 10.1088/1748-605X/ac0087.
Bio-adhesives are essential for wound healing because of their convenience and safety. Although widely used as biomaterials, silk fibroin's (SF's) further application as bio-adhesive is hindered due to its weak stickiness with tissue and slow gelation speed. Here, a dopamine-modified SF-based bio-adhesive is fabricated by using genipin as the chemical cross-linking agent. Furthermore, metal ions have been used to adjust the adhesion property of the bio-adhesive. The experimental results shows that the dopamine-modified SF-based composite holds a better stickiness except slow gelation speed. The doping of Cuand Fecan accelerate the gelation of the bio-adhesive. Compared with Cu, Fehas a stronger effect on the gelation speed of the bio-adhesive, which is positive correlative to the concentration of Fe. The adhesive has injectability and degradability. In addition, the SF-based adhesive has good biocompatibility and good improvement for cell migration. The SF-based bio-adhesive holds potential application in the field of rapid fixation of wounds.
生物黏合剂因其方便性和安全性而在伤口愈合中至关重要。尽管丝素蛋白 (SF) 作为生物材料得到了广泛应用，但由于其与组织的黏附力较弱和凝胶化速度较慢，其进一步作为生物黏合剂的应用受到了限制。在这里，使用京尼平作为化学交联剂制备了一种多巴胺修饰的 SF 基生物黏合剂。此外，还使用金属离子来调节生物黏合剂的黏附性能。实验结果表明，除了凝胶化速度较慢外，多巴胺修饰的 SF 基复合材料具有更好的黏附性。Cu 和 Fe 的掺杂可以加速生物黏合剂的凝胶化。与 Cu 相比，Fe 对生物黏合剂的凝胶化速度有更强的影响，与 Fe 的浓度呈正相关。该黏合剂具有可注射性和可降解性。此外，SF 基黏合剂具有良好的生物相容性和对细胞迁移的良好改善作用。SF 基生物黏合剂在伤口快速固定领域具有潜在的应用前景。
