School of Materials Science and Engineering, Nanyang Technological University, 639798, Singapore.
School of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, 710054 Xi'an, China.
ACS Appl Mater Interfaces. 2022 May 18;14(19):21945-21953. doi: 10.1021/acsami.2c02534. Epub 2022 May 4.
The adhesion between flexible epidermal sensors and human skin is essential for maintaining the stable functionality of the sensors. However, it is still challenging for epidermal electronic devices to achieve durable adhesion to the surface of the skin, especially under sweaty or humid conditions. Here, we report a silk fibroin-polyacrylamide (SF-PAAm) double network (DN) hydrogel adhesive with excellent biocompatibility, strong and durable adhesion on wet surfaces, and tunable adhesive properties. The hydrophilic PAAm network greatly improves the water retention capability of the DN hydrogel and reduces the β-sheet crystalline content of SF, leading to excellent adhesive properties of the hydrogel across a wide range of humidity. The SF-PAAm DN hydrogel adhesive can be readily integrated with different epidermal sensor arrays and performs very well in real-time on-body sweat sensing. The SF-PAAm DN hydrogels have great potential for application in various epidermal healthcare sensors as well as medical adhesives for other medical applications.
柔性表皮传感器与人体皮肤之间的黏附对于维持传感器的稳定功能至关重要。然而，对于表皮电子设备来说，实现与皮肤表面的持久黏附仍然具有挑战性，尤其是在多汗或潮湿的环境下。在这里，我们报道了一种丝素蛋白-聚丙烯酰胺（SF-PAAm）双重网络（DN）水凝胶粘合剂，它具有优异的生物相容性、在湿表面上的强且持久的黏附性以及可调节的黏附性能。亲水性的 PAAm 网络极大地提高了 DN 水凝胶的保水能力，并降低了 SF 的β-折叠结晶含量，从而使水凝胶在很宽的湿度范围内都具有优异的黏附性能。SF-PAAm DN 水凝胶粘合剂可以很容易地与不同的表皮传感器阵列集成，并在实时的体汗感测中表现出色。SF-PAAm DN 水凝胶在各种表皮保健传感器以及其他医疗应用的医疗粘合剂方面具有很大的应用潜力。
