Yap Jin Yi, Wan HItam Wan-Hazabbah, Abdul Halim Sanihah, Masnon Nurul Ain
Ophthalmology, University of Science Malaysia School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia
Surgical Department, University of Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.
BMJ Case Rep. 2021 May 12;14(5):e242082. doi: 10.1136/bcr-2021-242082.
We describe an uncommon cause of paraneoplastic optic neuropathy in adenocarcinoma of the lung. A 45-year-old healthy woman presented with seizure and encephalitis, followed by an acute visual loss in both eyes for 1 week. Her visual acuity was no perception of light in the right eye and hand movement in the left eye. There was a generalised restriction of extraocular muscle movements in both eyes. Funduscopy showed a bilateral pale optic disc. A paraneoplastic antigen autoimmune profile showed a positive anti-CV2/CRMP-5 antibody. CT of the thorax revealed the presence of right apical lung mass, confirmed to be adenocarcinoma through a biopsy. She was scheduled for lung lobectomy and chemotherapy. Unfortunately, her health deteriorated and she passed away eventually.
我们描述了一种肺癌所致副肿瘤性视神经病变的罕见病因。一名45岁健康女性先是出现癫痫发作和脑炎，随后双眼急性视力丧失1周。其右眼视力无光感，左眼视力仅能看到手动。双眼眼球运动均有广泛性受限。眼底检查显示双侧视盘苍白。副肿瘤抗原自身抗体谱显示抗CV2/CRMP-5抗体呈阳性。胸部CT显示右肺尖有肿块，经活检确诊为腺癌。她被安排接受肺叶切除术和化疗。不幸的是，她的健康状况恶化，最终去世。
