Preston-Martin S, Thomas D C, White S C, Cohen D
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033.
J Natl Cancer Inst. 1988 Aug 17;80(12):943-9. doi: 10.1093/jnci/80.12.943.
Findings from this population-based study in Los Angeles County suggest, for the first time, that tumors of the parotid gland are related to prior exposure to diagnostic medical and dental radiography. Responses to interviews with 408 patients with a parotid tumor (269 benign tumors and 139 malignant tumors) were compared to responses of 408 neighborhood controls. Cumulative exposure of the parotid gland from diagnostic radiography was associated with a dose-related increase in risk of malignant tumors (P for trend less than .05; relative risk for exposure to greater than or equal to 50 rad = 3.4; 95% confidence interval = 1.02-11.46). Benign tumors showed a weaker positive association, and exposure before age 20 to a major diagnostic examination (full-mouth or panoramic dental radiography or medical radiography to the head) increased risk (relative risk = 1.8; confidence interval = 1.13-2.91). This study also confirmed the association of malignant tumors with prior radiation treatment to the head or neck; 28% of these tumors are attributable to exposure of the parotid gland from diagnostic and therapeutic radiation.
这项基于洛杉矶县人群的研究结果首次表明，腮腺肿瘤与之前接受诊断性医疗和牙科放射摄影有关。对408例腮腺肿瘤患者（269例良性肿瘤和139例恶性肿瘤）的访谈回复与408名社区对照者的回复进行了比较。诊断性放射摄影对腮腺的累积暴露与恶性肿瘤风险的剂量相关增加有关（趋势P值小于0.05；暴露于大于或等于50拉德的相对风险=3.4；95%置信区间=1.02 - 11.46）。良性肿瘤显示出较弱的正相关，20岁之前接受一次主要诊断检查（全口或全景牙科放射摄影或头部医学放射摄影）会增加风险（相对风险=1.8；置信区间=1.13 - 2.91）。这项研究还证实了恶性肿瘤与之前头部或颈部放射治疗的关联；这些肿瘤中有28%可归因于诊断性和治疗性放射对腮腺的暴露。
