Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, 100850, China.
Sci Rep. 2021 May 12;11(1):10061. doi: 10.1038/s41598-021-89348-4.
Previous studies have shown that single-frequency microwave radiation can lead to cognitive decline in rats. However, few studies have focused on the combined effects of irradiation with different frequencies of microwaves. Our research aimed to investigate the effects of 1.5 GHz and 4.3 GHz microwave radiation, singly and in combination, on cognitive function and hippocampal tissue structure in rats. A total of 140 male Wistar rats were randomly divided into 4 groups: the S group (sham radiation group), L10 group (10 mW/cm 1.5 GHz group), C10 group (10 mW/cm 4.3 GHz band group) and LC10 group (10 mW/cm 1.5 and 4.3 GHz multi-frequency radiation group). For 1-28 days after microwave radiation, we analyzed the average escape latency for the Morris water maze task, electroencephalograms, change in hippocampal tissue structure and ultrastructure, content of the Nissl body in the hippocampus, and activities of lactate dehydrogenase and succinate dehydrogenase. Compared to the S group, all exposure groups showed varying degrees of learning and memory decline and hippocampal structural damage. The results showed that 1.5 GHz and 4.3 GHz microwave radiation was able to induce cognitive impairment and hippocampal tissue damage in rats and combined radiation with both frequencies caused more serious injuries, but none of these damaging effects varied with microwave frequency.
先前的研究表明，单一频率的微波辐射会导致大鼠认知能力下降。然而，很少有研究关注不同频率微波辐射的联合作用。我们的研究旨在探讨 1.5GHz 和 4.3GHz 微波辐射单独和联合辐射对大鼠认知功能和海马组织结构的影响。总共 140 只雄性 Wistar 大鼠被随机分为 4 组：S 组（假辐射组）、L10 组（10mW/cm 1.5GHz 组）、C10 组（10mW/cm 4.3GHz 频段组）和 LC10 组（10mW/cm 1.5 和 4.3GHz 多频辐射组）。在微波辐射后的 1-28 天内，我们分析了 Morris 水迷宫任务的平均逃逸潜伏期、脑电图、海马组织结构和超微结构变化、海马 Nissl 体含量以及乳酸脱氢酶和琥珀酸脱氢酶的活性。与 S 组相比，所有暴露组均表现出不同程度的学习和记忆能力下降以及海马结构损伤。结果表明，1.5GHz 和 4.3GHz 微波辐射可诱导大鼠认知障碍和海马组织损伤，两种频率的联合辐射造成更严重的损伤，但这些损伤效应均不随微波频率而变化。
