Wang Haoyu, Zhao Haixia, Li Chunfang, Dong Ji, Zhao Jianghao, Yue Hanlin, Lai Yunfei, Zhao Li, Wang Hui, Zhang Jing, Xu Xinping, Yao Binwei, Zhou Hongmei, Nie Binbin, Du Xiumin, Peng Ruiyun
Beijing Institute of Radiation Medicine, Beijing 100850, China.
College of Education, Hebei University, Baoding 071002, China.
Brain Sci. 2023 Jun 28;13(7):1006. doi: 10.3390/brainsci13071006.
Previous studies have suggested that microwave (MW) radiation with certain parameters can induce spatial memory deficits. However, the effect of MW on the topological organization of the brain network is still unknown. This work aimed to investigate the topological organization of the brain network in rats with spatial memory impairments induced by acute microwave (MW) radiation. The Morris water maze (MWM) test and resting-state functional magnetic resonance imaging were performed to estimate the spatial memory ability and brain network topological organization of the rats after MW exposure. Compared with the sham group, the rats exposed to 30 mW/cm 1.5 GHz MW radiation exhibited a significantly decreased normalized clustering coefficient (γ) ( = 0.002) 1 d after the exposure and a prolonged average escape latency (AEL) ( = 0.014) 3 d after the exposure. Moreover, after 10 mW/cm 1.5 GHz MW radiation, a significantly decreased γ ( = 0.003) was also observed in the rats, without any changes in AEL. In contrast, no adverse effects on AEL or topological parameters were observed after 9.375 GHz MW radiation. In conclusion, the rats with spatial memory deficits induced by MW radiation exhibited disruptions in the topological organization of the brain network. Moreover, these topological organization disruptions emerged earlier than behavioral symptom onset and could even be found in the rats without a decline in the performance of the spatial memory task. Therefore, it is possible to use the topological parameters of the brain network as early and sensitive indicators of the spatial memory impairments induced by acute MW radiation.
先前的研究表明，具有特定参数的微波（MW）辐射可诱发空间记忆缺陷。然而，MW对脑网络拓扑组织的影响仍不清楚。这项工作旨在研究急性微波（MW）辐射诱导的空间记忆受损大鼠的脑网络拓扑组织。进行了莫里斯水迷宫（MWM）测试和静息态功能磁共振成像，以评估MW暴露后大鼠的空间记忆能力和脑网络拓扑组织。与假手术组相比，暴露于30 mW/cm 1.5 GHz MW辐射的大鼠在暴露后1天表现出归一化聚类系数（γ）显著降低（ = 0.002），在暴露后3天平均逃避潜伏期（AEL）延长（ = 0.014）。此外，在10 mW/cm 1.5 GHz MW辐射后，大鼠中也观察到γ显著降低（ = 0.003），而AEL没有任何变化。相比之下，9.375 GHz MW辐射后未观察到对AEL或拓扑参数的不利影响。总之，MW辐射诱导的空间记忆缺陷大鼠的脑网络拓扑组织出现破坏。此外，这些拓扑组织破坏比行为症状出现更早，甚至在空间记忆任务表现未下降的大鼠中也能发现。因此，有可能将脑网络的拓扑参数用作急性MW辐射诱导的空间记忆损伤的早期敏感指标。
