Molecular Psychiatry Laboratory, Department of Psychiatry, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Department of Mental Health, Israel Defense Forces, Ramat Gan, Israel.
Mol Psychiatry. 2021 Nov;26(11):6680-6687. doi: 10.1038/s41380-021-01107-z. Epub 2021 May 12.
Childhood adversity (CA) may alter reactivity to stress throughout life, increasing risk for psychiatric and medical morbidity, yet long-term correlates of milder CA levels among high functioning healthy adolescents are less studied. The current study examined the prevalence and impact of CA exposure among a cohort of healthy motivated elite parachute unit volunteers, prospectively assessed at rest and at the height of an intensive combat-simulation exposure. We found significantly reduced gene expression levels in resting mononuclear cell nuclear receptor, subfamily 3, member 1 (NR3C1), and its transactivator spindle and kinetochore-associated protein 2 (SKA2), that predict blunted cortisol reactivity to combat-simulation stress among CA exposed adolescents. Long-term alterations in endocrine immune indices, subjective distress, and executive functions persist among healthy high functioning adolescents following milder CA exposure, and may promote resilience or vulnerability to later real-life combat exposure.
儿童逆境（CA）可能会改变一生对压力的反应，增加精神和医疗发病的风险，但针对高功能健康青少年中轻度 CA 水平的长期相关性研究较少。本研究在一个健康有动力的精英跳伞部队志愿者队列中检查了 CA 暴露的流行率和影响，前瞻性地在休息时和紧张的战斗模拟暴露时进行评估。我们发现，在休息时的单核细胞核受体亚家族 3 成员 1（NR3C1）及其转录激活剂纺锤体和动粒相关蛋白 2（SKA2）中，基因表达水平显著降低，这预示着在 CA 暴露的青少年中，皮质醇对战斗模拟应激的反应迟钝。在经历轻度 CA 暴露后，健康高功能青少年的内分泌免疫指标、主观痛苦和执行功能仍会长期发生变化，这可能会增加他们对以后现实生活中战斗暴露的适应能力或易感性。
