Wu Xuan, Duan Zuowei, Liu Yihui, Zhou Changwu, Jiao Zhiyun, Zhao Yi, Tang Tieyu
Department of Neurology, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Department of Medical Imaging, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Front Neurol. 2021 Apr 26;12:613027. doi: 10.3389/fneur.2021.613027. eCollection 2021.
This study was to examine the patients with acute cerebral infarction (ACI) treated at a single center over 9 years and who underwent Unruptured intracranial aneurysm (UIA) screening by three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA), and to explore the factors associated with outcomes. The outcome was the modified Rankin scale (mRS) score at 90 days after stroke onset. The outcome was classified into a good outcome (mRS score of 0-2 points) and poor outcome (mRS score of 3-6 points). UIAs were found in 260 (6.5%) of 4,033 patients with ACI; 2,543 (63.1%) had a good outcome, and 1,490 (36.9%) had a poor outcome. There was no difference in outcomes between the two groups ( = 0.785). The multivariable analysis showed that age (OR = 1.009, 95%CI: 1.003-1.014, = 0.003), diabetes (OR = 1.179, 95%CI: 1.035-1.342, = 0.013), ischemic stroke history (OR = 1.451, 95%CI: 1.256-1.677, < 0.001), and baseline NIHSS score (OR = 1.034, 95%CI: 1.018-1.050, < 0.001) were independently associated with the 90-day outcomes in patients with ACI. The presence of incidental UIA was not associated with outcomes after ACI. Age, diabetes, ischemic stroke history, and baseline NIHSS score were independently associated with the early outcomes of patients with ACI.
本研究旨在对在单一中心接受治疗超过9年且通过三维时间飞跃磁共振血管造影（3D-TOF-MRA）进行未破裂颅内动脉瘤（UIA）筛查的急性脑梗死（ACI）患者进行检查，并探索与预后相关的因素。结局指标为卒中发病后90天的改良Rankin量表（mRS）评分。结局分为良好结局（mRS评分为0 - 2分）和不良结局（mRS评分为3 - 6分）。在4033例ACI患者中，有260例（6.5%）发现了UIA；2543例（63.1%）预后良好，1490例（36.9%）预后不良。两组间结局无差异（= 0.785）。多变量分析显示，年龄（OR = 1.009，95%CI：1.003 - 1.014，= 0.003）、糖尿病（OR = 1.179，95%CI：1.035 - 1.342，= 0.013）、缺血性卒中病史（OR = 1.451，95%CI：1.256 - 1.677，< 0.001）以及基线美国国立卫生研究院卒中量表（NIHSS）评分（OR = 1.034，95%CI：1.018 - 1.050，< 0.001）与ACI患者90天结局独立相关。偶然发现的UIA的存在与ACI后的结局无关。年龄、糖尿病、缺血性卒中病史和基线NIHSS评分与ACI患者的早期结局独立相关。
