Bahadori Arya, Khan Munad, Abdi Ehtesham, Arnold Colin
The Tweed Hospital, Tweed Heads, NSW, 2485, Australia.
Griffith University, Gold Coast, QLD, 4222, Australia.
Urol Case Rep. 2021 Mar 26;38:101646. doi: 10.1016/j.eucr.2021.101646. eCollection 2021 Sep.
Metastatic urothelial carcinoma of the bladder is generally considered to be an aggressive disease with many recognised variants, however what is unique about our patient is the metastatic transformation from a urothelial primary malignancy with sarcomatoid variation to a neuroendocrine deposit within the liver. From what we have identified, this pattern of pathological transformation has not been reported for a urothelial malignancy in the literature. We present a 64 year old male who we believe is the first reported case of a primary urothelial malignancy presenting de-novo with metastatic liver deposits showing neuro-endocrine transformation.
膀胱转移性尿路上皮癌通常被认为是一种侵袭性疾病，有许多公认的变异类型，然而我们的患者的独特之处在于，其从具有肉瘤样变异的尿路上皮原发性恶性肿瘤转移转变为肝脏内的神经内分泌沉积物。据我们所知，这种病理转变模式在文献中尚未见尿路上皮恶性肿瘤的报道。我们报告一名64岁男性，我们认为他是首例原发性尿路上皮恶性肿瘤初发时即伴有肝脏转移灶并显示神经内分泌转变的报道病例。
