Mori Hidetsugu, Takahashi Kanji
Department of Ophthalmology, Kansai Medical University, Osaka, Japan.
Ocul Oncol Pathol. 2021 Mar;7(2):97-102. doi: 10.1159/000508891. Epub 2020 Dec 18.
A 78-year-old female experienced extraocular extension of a giant conjunctival melanocytic mass. The clinical diagnosis was conjunctival malignant melanoma. We performed local excision and histopathological examination. The result of hematoxylin-eosin staining disclosed multiple intralesional mucosal cysts and nevus cell nests with abundant melanin. Immunohistochemical examination revealed expression of S-100, melan-A, and HMB-45 and no expression of Ki-67. Histopathological examination showed no evidence of malignancy. Giant conjunctival melanocytic nevi can be diagnostically confused with conjunctival malignant melanoma.
一名78岁女性出现巨大结膜黑素细胞性肿物向眼外扩展。临床诊断为结膜恶性黑色素瘤。我们进行了局部切除及组织病理学检查。苏木精-伊红染色结果显示病变内有多个黏膜囊肿和含丰富黑色素的痣细胞巢。免疫组织化学检查显示S-100、黑素-A和HMB-45表达阳性，Ki-67表达阴性。组织病理学检查未发现恶性证据。巨大结膜黑素细胞痣在诊断上可能会与结膜恶性黑色素瘤相混淆。
