Gerner N, Nørregaard J C, Jensen O A, Prause J U
Department of Ophthalmology, Copenhagen University Hospital, Hvidovre, Denmark.
Acta Ophthalmol Scand. 1996 Aug;74(4):334-7. doi: 10.1111/j.1600-0420.1996.tb00703.x.
The clinicopathological characteristics of 343 naevi of the conjunctiva were studied. A significant increase in the number of naevi excised per annum was observed. This may have been caused by an increased exposure to actinic rays. Approximately even distribution in the three main locations: caruncle, limbal area and eyeball, was found. Intrastromal naevi were excised at a higher median age than compound naevi, and the lowest observed median age at excision was for junction naevi, which is in accordance with the known histopathological nature of naevi. Recurrence occurred in nine patients (2.7%), and one transformed to a malignant melanoma. Eight of the recurring naevi were located in the limbal area. Eight of the nine patients were women, suggesting hormonal factors as a possible cause. Recommendations for the handling of conjunctival naevi are given, based on the present findings and on previous reports.
对343例结膜痣的临床病理特征进行了研究。观察到每年切除的痣数量显著增加。这可能是由于日光射线暴露增加所致。发现在三个主要部位：泪阜、角膜缘区和眼球，分布大致均匀。基质内痣切除的中位年龄高于复合痣，观察到的最低切除中位年龄是交界痣，这与痣已知的组织病理学性质相符。9例患者（2.7%）出现复发，1例转变为恶性黑色素瘤。8例复发性痣位于角膜缘区。9例患者中有8例为女性，提示激素因素可能是一个原因。根据目前的研究结果和既往报告，给出了结膜痣处理的建议。
