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基础提示:如何开始对帕金森病患者进行脑深部电刺激编程?

Basic Tips: How Do I Start Programming Deep Brain Stimulation in Parkinson Disease Patients?

作者信息

Gorodetsky Carolina, Fasano Alfonso

机构信息

Division of Neurology The Hospital for Sick Children Toronto Ontario Canada.

Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic Toronto Western Hospital, UHN Toronto Ontario Canada.

出版信息

Mov Disord Clin Pract. 2021 Apr 6;8(4):639-644. doi: 10.1002/mdc3.13203. eCollection 2021 May.

DOI:10.1002/mdc3.13203
PMID:33981807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8088109/
Abstract

Deep brain stimulation (DBS) has become an integral component of Parkinson disease treatment. Programming a DBS device is a time-consuming process and requires a highly trained specialist to obtain optimal results. During the last few years, we have witnessed a rapid technological advance of DBS systems, making the programming process even more complex and emphasizing the need for a structured approach. In this manuscript and the attached videos, we will demonstrate a step-by-step programming approach for DBS targeting the subthalamus and the globus pallidus pars Interna. In doing so we will show the main features and differences of the three main systems available on the market, including the newest ones able to record braingenerated local field potentials for clinical applications.

摘要

脑深部电刺激(DBS)已成为帕金森病治疗的一个重要组成部分。对DBS设备进行编程是一个耗时的过程,需要训练有素的专家才能获得最佳效果。在过去几年中,我们见证了DBS系统的迅速技术进步,这使得编程过程更加复杂,并凸显了采用结构化方法的必要性。在本手稿及随附视频中,我们将演示针对丘脑底核和苍白球内侧部进行DBS的逐步编程方法。在此过程中,我们将展示市场上三种主要系统的主要特点和差异,包括能够记录脑源性局部场电位以供临床应用的最新系统。

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Subthalamic nucleus deep brain stimulation programming settings do not correlate with Parkinson's disease severity.苍白球内侧部脑深部电刺激术的刺激参数与帕金森病严重程度无关。
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本文引用的文献

1
Technology of deep brain stimulation: current status and future directions.深部脑刺激技术:现状与未来方向。
Nat Rev Neurol. 2021 Feb;17(2):75-87. doi: 10.1038/s41582-020-00426-z. Epub 2020 Nov 26.
2
Update on Current Technologies for Deep Brain Stimulation in Parkinson's Disease.帕金森病深部脑刺激的当前技术进展
J Mov Disord. 2020 Sep;13(3):185-198. doi: 10.14802/jmd.20052. Epub 2020 Aug 31.
3
Deep brain stimulation programming in Parkinson's disease: Introduction of current issues and perspectives.帕金森病的脑深部电刺激程控:当前问题与展望介绍
Rev Neurol (Paris). 2020 Dec;176(10):770-779. doi: 10.1016/j.neurol.2020.02.009. Epub 2020 Apr 15.
4
Novel Deep Brain Stimulation Technologies for Parkinson's Disease: More Expectations, More Frustrations?用于帕金森病的新型深部脑刺激技术:期望更多,失望更多?
Mov Disord Clin Pract. 2019 Nov 14;7(1):113-114. doi: 10.1002/mdc3.12847. eCollection 2020 Jan.
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Programming Deep Brain Stimulation for Parkinson's Disease: The Toronto Western Hospital Algorithms.深部脑刺激程控治疗帕金森病:多伦多西部医院算法。
Brain Stimul. 2016 May-Jun;9(3):425-437. doi: 10.1016/j.brs.2016.02.004. Epub 2016 Feb 12.