使用正性 Pavlovian 条件作用量化绒猴的快感缺失样症状。
Quantifying anhedonia-like symptoms in marmosets using appetitive Pavlovian conditioning.
机构信息
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK.
出版信息
STAR Protoc. 2021 Apr 17;2(2):100454. doi: 10.1016/j.xpro.2021.100454. eCollection 2021 Jun 18.
Blunted reward responsivity is associated with anhedonia in humans and is a core feature of depression. This protocol describes how to train the common marmoset, , on an appetitive Pavlovian conditioning paradigm to measure behavioral and cardiovascular correlates of anticipatory and consummatory phases of reward processing. We describe how to use intracerebral infusions to manipulate brain regions whose activity is relevant to impaired reward processing in depression and how the paradigm can be used to test antidepressant efficacy. For complete details on the use and execution of this protocol, please refer to Alexander et al. (2019).
奖赏反应迟钝与快感缺失有关，是抑郁症的核心特征。本方案描述了如何对普通狨猴进行正强化条件反射范式训练，以测量奖赏加工的预期和满足阶段的行为和心血管相关物。我们描述了如何使用脑内输注来操纵与抑郁症中受损奖赏加工相关的脑区的活动，以及如何使用该范式来测试抗抑郁药的疗效。有关该方案使用和执行的完整详细信息，请参阅 Alexander 等人（2019 年）。
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