Braesicke Katrin, Parkinson John A, Reekie Yvonna, Man Mei-See, Hopewell Lucy, Pears Andrew, Crofts Harriet, Schnell Christian R, Roberts Angela C
Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK.
Eur J Neurosci. 2005 Mar;21(6):1733-40. doi: 10.1111/j.1460-9568.2005.03987.x.
Central to many emotional responses is the accompanying peripheral somatic and autonomic arousal, feedback from which has been hypothesized to enhance emotional memory and to contribute to appraisal processes and decision making, and dysfunction of which may contribute to antisocial behaviour. Whilst peripheral arousal may accompany both positive and negative emotional contexts, its relationship with the former is poorly understood, as are the neural mechanisms underlying such a relationship. The purpose of the present study was to determine the autonomic correlates of anticipation, as well as consumption, of high incentive food, in the freely moving common marmoset and to investigate the contribution of the amygdala to such effects. Blood pressure (BP) and heart rate (HR) were measured remotely by a telemetric device implanted into the descending aorta and behavioural responses were monitored whilst marmosets viewed preferred or non-preferred foods and were then allowed access to eat those foods. A marked rise in blood pressure in unrestrained marmosets was observed in response both to the sight of highly preferred foods (anticipatory period) as well as during the actual consumption of those foods (consummatory period). Excitotoxic lesions of the amygdala abolished the autonomic arousal in the anticipatory period, but spared both the behavioural arousal in the anticipatory period and the autonomic arousal in the consummatory period. Together these data serve as an important step towards understanding the role of autonomic arousal in emotion and its neural underpinnings.
许多情绪反应的核心是伴随的外周躯体和自主神经唤醒，据推测，来自外周的反馈会增强情绪记忆，并有助于评估过程和决策，而外周功能障碍可能导致反社会行为。虽然外周唤醒可能伴随积极和消极的情绪情境，但人们对其与积极情绪情境的关系以及这种关系背后的神经机制了解甚少。本研究的目的是确定自由活动的普通狨猴在预期和食用高奖励食物时的自主神经关联，并研究杏仁核在这些效应中的作用。通过植入降主动脉的遥测设备远程测量血压（BP）和心率（HR），并在狨猴观看偏好或非偏好食物然后被允许进食这些食物时监测其行为反应。在不受约束的狨猴中，无论是看到高度偏好的食物（预期期）还是在实际食用这些食物（ consummatory期）时，都观察到血压显著升高。杏仁核的兴奋性毒性损伤消除了预期期的自主神经唤醒，但保留了预期期的行为唤醒和 consummatory期的自主神经唤醒。这些数据共同为理解自主神经唤醒在情绪中的作用及其神经基础迈出了重要一步。
