Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
Org Biomol Chem. 2021 Jun 2;19(21):4652-4677. doi: 10.1039/d1ob00601k.
The ubiquity of anions in biological and environmental systems has motivated the development of many novel anion receptors and sensors over the past two decades. Optical anion sensors, which undergo a spectral change in response to anion binding, are particularly desirable due to the technical simplicity and fast response time of such systems. A myriad of macrocyclic host molecules have been shown to be effective anion receptors and present a promising platform for elaboration into optical anion sensors by incorporation of an appropriate fluorogenic or chromogenic group. The enhanced anion binding properties of the three-dimensional binding cavities in mechanically interlocked host molecules have also been exploited to design anion sensors that exhibit remarkable selectivity and sensitivity. This review summarises recent progress in the development of optical anion sensors based on macrocyclic and interlocked hosts. The major classes of macrocyclic receptors possessing neutral, cationic and metal-based binding motifs are examined, followed by a survey of optically-responsive interlocked anion hosts.
在过去的二十年中，由于阴离子在生物和环境系统中的普遍存在，许多新型阴离子受体和传感器得到了发展。光学阴离子传感器对阴离子结合具有光谱变化响应，由于这些系统的技术简单性和快速响应时间，因此特别理想。已经证明，许多大环主体分子是有效的阴离子受体，并为通过引入适当的荧光团或生色团而将其设计成光学阴离子传感器提供了有前途的平台。机械互锁主体分子中三维结合腔的增强阴离子结合特性也被用于设计表现出显著选择性和灵敏度的阴离子传感器。本文综述了基于大环和互锁主体的光学阴离子传感器的最新进展。检查了具有中性、阳离子和基于金属的结合基序的主要大环受体类别，然后对光响应互锁阴离子主体进行了调查。
