Special Academic Unit of Health Sciences (UAE-CISAU), Federal University of Jataí (UFJ), Jataí, Brazil.
Department of Surgery-Faculty of Medical Sciences, State University of Campinas (UNICAMP), Rua Alexander Fleming, s/nº, Cidade Universitaria Zeferino Vaz, Campinas, SP, CEP 13085-000, Brazil.
Obes Surg. 2021 Aug;31(8):3675-3685. doi: 10.1007/s11695-021-05470-2. Epub 2021 May 12.
We hypothesize that non-alcoholic fatty liver disease (NAFLD) may be significantly associated with waist circumference (WC), neck circumference (NC), hip circumference (HC), and waist-to-hip ratio (WHR).
To analyze correlations between anthropometric parameters and the occurrence and intensity of NAFLD aspects assessed by histopathological examination in individuals undergoing bariatric surgery.
This is a cross-sectional study carried out in a tertiary university hospital. Demographic, clinical, anthropometric, laboratory, and histopathological variables were analyzed; uni- and multivariate analyses were performed. Histopathological variables analyzed were findings of liver biopsies collected during surgical procedures.
Of 119 individuals, 105 (88.2%) were female. The mean age was 38.8 ± 9.3 years and the mean BMI was 37.6 ± 3.1 kg/m. The prevalence of NAFLD histopathological aspects was: steatosis (76.5%), steatohepatitis (49.6%), and fibrosis (51.3%). WC was significantly higher in individuals with steatosis (103.5 ± 9.9 vs. 99.4 ± 8.4; p = 0.03). Individuals with steatohepatitis presented significantly higher BMI (38.2 ± 3.2 vs. 36.7 ± 2.8; p = 0.01), WC (105.3 ± 10.4 vs. 99.6 ± 8.8; p = 0.002), and WHR (1 ± 0.1 vs. 0.9 ± 0.1; p = 0.02). Age (40.6 ± 9.7 vs. 37 ± 8.5; p = 0.03) and hemoglobin A1c (6.5 ± 0.5 vs. 5.6 ± 0.5; p = 0.004) were significantly higher among individuals with fibrosis. A positive correlation was observed between the steatosis intensity and WHR (R = 0.2; p = 0.04). BMI (R = 0.2; p = 0.02) and glucose (R = 0.2; p = 0.009) were independently correlated with the steatohepatitis intensity. Age (R = 0.3; p = 0.04) was independently correlated with the fibrosis intensity.
There were significant associations between anthropometric parameters and NAFLD aspects. WC and WHR were associated with steatosis; BMI, WC, and WHR were associated with steatohepatitis. WHR independently correlated with steatosis intensity.
我们假设非酒精性脂肪性肝病（NAFLD）可能与腰围（WC）、颈围（NC）、臀围（HC）和腰臀比（WHR）显著相关。
分析在接受减重手术的个体中，人体测量参数与通过组织病理学检查评估的 NAFLD 各方面的发生和严重程度之间的相关性。
这是一项在三级大学医院进行的横断面研究。分析了人口统计学、临床、人体测量、实验室和组织病理学变量；进行了单变量和多变量分析。分析的组织病理学变量是手术过程中收集的肝活检的发现。
在 119 名个体中，有 105 名（88.2%）为女性。平均年龄为 38.8 ± 9.3 岁，平均 BMI 为 37.6 ± 3.1 kg/m。NAFLD 组织病理学方面的患病率为：脂肪变性（76.5%）、脂肪性肝炎（49.6%）和纤维化（51.3%）。脂肪变性患者的 WC 明显更高（103.5 ± 9.9 与 99.4 ± 8.4；p = 0.03）。脂肪性肝炎患者的 BMI（38.2 ± 3.2 与 36.7 ± 2.8；p = 0.01）、WC（105.3 ± 10.4 与 99.6 ± 8.8；p = 0.002）和 WHR（1 ± 0.1 与 0.9 ± 0.1；p = 0.02）明显更高。纤维化患者的年龄（40.6 ± 9.7 与 37 ± 8.5；p = 0.03）和血红蛋白 A1c（6.5 ± 0.5 与 5.6 ± 0.5；p = 0.004）明显更高。脂肪变性的严重程度与 WHR 呈正相关（R = 0.2；p = 0.04）。BMI（R = 0.2；p = 0.02）和葡萄糖（R = 0.2；p = 0.009）与脂肪性肝炎的严重程度独立相关。年龄（R = 0.3；p = 0.04）与纤维化的严重程度独立相关。
人体测量参数与 NAFLD 各方面之间存在显著关联。WC 和 WHR 与脂肪变性相关；BMI、WC 和 WHR 与脂肪性肝炎相关。WHR 与脂肪变性的严重程度独立相关。
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