Suri Shalini, Singh Shraddha, Rapelly Sushma Swaraj, Rungta Sumit, Ahmad Ehsan
Department of Physiology, King George Medical University Lucknow, Uttar Pradesh, India.
Department of Gastromedicine, King George Medical University Lucknow, Uttar Pradesh, India.
J Family Med Prim Care. 2025 Mar;14(3):1073-1078. doi: 10.4103/jfmpc.jfmpc_1464_24. Epub 2025 Mar 25.
Non-alcoholic fatty liver disease (NAFLD) may in some cases progress to increasing grades of liver fibrosis and eventually cirrhosis. NAFLD patients often succumb to cardiovascular causes. Previous studies have linked visceral fat, a known cardiovascular risk factor, to NAFLD. Visceral fat is best quantified by measuring the waist circumference (WC). This study is aimed to determine the association of waist circumference with severity of liver fibrosis in NAFLD patients.
In this cross-sectional study we recruited 82 NAFLD patients diagnosed via ultrasonography. They underwent anthropometric examination followed by transient elastography with Fibro Scan to assess of liver stiffness measure (LSM). A cutoff LSM value of 7kPa was used to indicate significant fibrosis. Among the participants, 40 patients had an LSM value of <7 kPa (insignificant/no fibrosis), while 42 were found to have >7 kPa (significant fibrosis). Biochemical parameters of Lipid profile and Liver enzymes were also analyzed.
SPSS software with Student -test, Chi-square -test, ANOVA, and Spearman correlation with 95% CI is used. <0.05 is considered significant.
Patients with significant fibrosis had higher mean weight ( < 0.001), BMI ( = 0.009), WC ( = 0.002), and waist-hip ratio (WHR, = 0.032) compared to those with no fibrosis. However, hip circumference (HC) was not significantly associated between the two groups. In correlation studies, BMI ( = 0.001), weight ( < 0.001), WC ( = 0.001), and HC ( = 0.008) positively correlated with severity of liver fibrosis in NAFLD patients. However, no significant correlation was found with WHR.
Weight, BMI, and visceral fat indicators like WC and WHR are strongly associated with liver fibrosis severity in NAFLD patients. Notably, weight, BMI, WC, and HC positively correlate with fibrosis severity, while WHR does not. Early diagnosis of fatty liver is crucial to prevent progression to life-threatening conditions like NASH or NASH cirrhosis. Waist circumference could serve as a practical screening tool in primary health care centres for identifying NAFLD patients at risk of fibrosis progression.
非酒精性脂肪性肝病（NAFLD）在某些情况下可能会发展为肝纤维化程度加重，最终发展为肝硬化。NAFLD患者常死于心血管疾病。先前的研究已将内脏脂肪（一种已知的心血管危险因素）与NAFLD联系起来。内脏脂肪最好通过测量腰围（WC）来量化。本研究旨在确定NAFLD患者腰围与肝纤维化严重程度之间的关联。
在这项横断面研究中，我们招募了82名经超声诊断的NAFLD患者。他们接受了人体测量检查，随后使用Fibro Scan进行瞬时弹性成像以评估肝脏硬度值（LSM）。LSM值的临界值为7kPa用于指示显著纤维化。在参与者中，40名患者的LSM值<7kPa（无显著纤维化/无纤维化），而42名患者的LSM值>7kPa（显著纤维化）。还分析了血脂和肝酶的生化参数。
使用具有学生检验、卡方检验、方差分析和95%置信区间的Spearman相关性的SPSS软件。P<0.05被认为具有显著性。
与无纤维化的患者相比，显著纤维化的患者平均体重更高（P<0.001）、BMI更高（P=0.009）、WC更高（P=0.002）和腰臀比（WHR，P=0.032）更高。然而，两组之间臀围（HC）没有显著关联。在相关性研究中，BMI（P=0.001）、体重（P<0.001）、WC（P=0.001）和HC（P=0.008）与NAFLD患者肝纤维化的严重程度呈正相关。然而，未发现与WHR有显著相关性。
体重、BMI以及诸如WC和WHR等内脏脂肪指标与NAFLD患者的肝纤维化严重程度密切相关。值得注意的是，体重、BMI、WC和HC与纤维化严重程度呈正相关，而WHR则不然。早期诊断脂肪肝对于预防发展为诸如非酒精性脂肪性肝炎（NASH）或NASH肝硬化等危及生命的疾病至关重要。腰围可作为初级保健中心识别有纤维化进展风险的NAFLD患者的实用筛查工具。
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