Ciprandi G, Damiani V, Passali F M, Crisanti A, Motta G, Passali D
Consultant allergist, Casa di Cura Villa Montallegro, Genoa, Italy.
Medical Department, D.M.G. Italia, Pomezia, Italy.
J Biol Regul Homeost Agents. 2021 Jan-Feb;35(1 Suppl. 2):61-64. doi: 10.23812/21-1supp2-12.
Laryngopharyngeal reflux (LPR) is a common disease caused by the leaking beck of gastric material out of the esophagus. The main symptoms are dysphonia, dysphagia, and cough. There is an established use of proton pump inhibitors (PPI) in patients with suspected LPR in common practice. This habit is translated by the standard strategy to use PPI in treating patients with gastroesophageal reflux. However, PPI can not wholly inhibit all types of reflux and are burden by adverse effects. Alginate, a derivative from algae, is devoid of side effects and effectively counteracts gastric material reflux forming a foaming gel in the stomach. The current study enrolled 100 outpatients with LPR. Alginate treatment was administered for two months. Patients underwent four visits (at baseline and 15, 30, and 60 days after treatment). A visual analog scale assessed the perception of dysphonia, dysphagia, and cough. Alginate significantly (p<0.0001) reduced all parameters. Therefore, the current study demonstrated that magnesium alginate was effective and safe in LPR treatment.
喉咽反流（LPR）是一种由胃内容物从食管反流引起的常见疾病。主要症状为声音嘶哑、吞咽困难和咳嗽。在临床实践中，对于疑似LPR的患者，质子泵抑制剂（PPI）的使用已得到确立。这种习惯是按照治疗胃食管反流患者使用PPI的标准策略转变而来的。然而，PPI不能完全抑制所有类型的反流，且存在不良反应负担。藻酸盐是一种藻类衍生物，无副作用，能有效对抗胃内容物反流，在胃中形成泡沫凝胶。本研究纳入了100例LPR门诊患者。给予藻酸盐治疗两个月。患者接受了四次就诊（基线时以及治疗后15、30和60天）。采用视觉模拟量表评估声音嘶哑、吞咽困难和咳嗽的感受。藻酸盐显著（p<0.0001）降低了所有参数。因此，本研究表明海藻酸镁在LPR治疗中有效且安全。
