Koch Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
CA Cancer J Clin. 2021 Jul;71(4):333-358. doi: 10.3322/caac.21670. Epub 2021 May 13.
Cancer has myriad effects on metabolism that include both rewiring of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment, and changes in normal tissue metabolism. With the recognition that fluorodeoxyglucose-positron emission tomography imaging is an important tool for the management of many cancers, other metabolites in biological samples have been in the spotlight for cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecule metabolites that like other -omics technologies can provide critical information about the cancer state that are otherwise not apparent. Here, the authors review how cancer and cancer therapies interact with metabolism at the cellular and systemic levels. An overview of metabolomics is provided with a focus on currently available technologies and how they have been applied in the clinical and translational research setting. The authors also discuss how metabolomics could be further leveraged in the future to improve the management of patients with cancer.
癌症对代谢有多种影响，包括重新布线细胞内代谢以使癌细胞异常增殖并适应肿瘤微环境，以及正常组织代谢的变化。随着人们认识到氟脱氧葡萄糖正电子发射断层扫描成像（FDG-PET）是许多癌症管理的重要工具，生物样本中的其他代谢物也成为癌症诊断、监测和治疗的焦点。代谢组学是对小分子代谢物的全面分析，与其他组学技术一样，它可以提供有关癌症状态的关键信息，而这些信息在其他情况下并不明显。在这里，作者综述了癌症及其治疗方法如何在细胞和全身水平上与代谢相互作用。作者提供了代谢组学的概述，重点介绍了目前可用的技术以及它们在临床和转化研究中的应用。作者还讨论了代谢组学如何在未来得到进一步利用，以改善癌症患者的治疗效果。
