Institute of Convergence Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea.
Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Adv Exp Med Biol. 2021;1187:283-301. doi: 10.1007/978-981-32-9620-6_14.
Patient-derived xenograft (PDX) model can be used as a platform to study the individual patient's sensitivity to targeted agents as well as its ability to guide our understanding in various aspects of tumor biology including the tumor's clonal evolution and interaction with microenvironment. In this chapter, we review the history of PDX models in various tumor types. Additionally, we highlight the key studies that suggested potential value of PDX models in cancer treatment. Specifically, we will briefly introduce several studies on the issue of PDX models for precision medicine. In latter part of this chapter, we focus on the studies that used PDX models to investigate the molecular biology of breast cancer that underlies the process of drug resistance and tumor metastasis. Also, we will address our own experience in developing PDX models using breast cancer tissues from Korean breast cancer patients.
患者来源的异种移植（PDX）模型可用作研究个体患者对靶向药物的敏感性的平台，以及指导我们了解肿瘤生物学各个方面的能力，包括肿瘤的克隆进化及其与微环境的相互作用。在本章中，我们回顾了各种肿瘤类型中 PDX 模型的历史。此外，我们还重点介绍了一些提示 PDX 模型在癌症治疗中具有潜在价值的关键研究。具体来说，我们将简要介绍几个关于 PDX 模型用于精准医学的研究。在本章的后半部分，我们将重点介绍使用 PDX 模型研究乳腺癌的分子生物学的研究，这些研究涉及药物耐药性和肿瘤转移的过程。此外，我们还将介绍我们自己使用韩国乳腺癌患者的乳腺癌组织开发 PDX 模型的经验。
