Xiao Junyan, Zhao Chan, Zhang Yang, Liang Anyi, Qu Yi, Cheng Gangwei, Zhang Meifen
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
Ocul Immunol Inflamm. 2022 Oct-Nov;30(7-8):1617-1624. doi: 10.1080/09273948.2021.1924385. Epub 2021 May 13.
To evaluate the clinical safety and efficacy of modified CO laser-assisted sclerectomy surgery (CLASS) in patients with uveitic glaucoma (UG) using primary open-angle glaucoma (POAG) patients for a comparison.
This retrospective study included UG and POAG patients from the modified CLASS Study Group database. Intraocular pressure (IOP) and the number of glaucoma medications were compared between groups by the Wilcoxon test. The Kaplan-Meier method was used for survival analysis; complete success was defined as 5≤ IOP≤18 mmHg and a ≥ 20% reduction in IOP from baseline without medication.
Twenty-three and 25 eyes in UG and POAG groups were included. At the 12-month visit in both groups, the mean IOP and mean number of IOP-lowering medications were significantly reduced compared to baseline, with complete success rates of 60.9% and 64.0% in the UG and POAG groups ( = .859).
Modified CLASS yields similar outcomes for patients with UG and POAG.
以原发性开角型青光眼（POAG）患者作为对照，评估改良式CO激光辅助巩膜切除术（CLASS）治疗葡萄膜炎性青光眼（UG）患者的临床安全性和疗效。
这项回顾性研究纳入了改良CLASS研究组数据库中的UG和POAG患者。通过Wilcoxon检验比较两组之间的眼压（IOP）和青光眼药物使用数量。采用Kaplan-Meier方法进行生存分析；完全成功定义为眼压5≤IOP≤18 mmHg且眼压较基线水平降低≥20%且无需药物治疗。
UG组和POAG组分别纳入23只和25只眼睛。在两组的12个月随访中，与基线相比，平均眼压和降眼压药物的平均使用数量均显著降低，UG组和POAG组的完全成功率分别为60.9%和64.0%（P = 0.859）。
改良式CLASS治疗UG和POAG患者的效果相似。
