Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
Department of Bioengineering, University of Washington, Seattle, Washington, United States.
Invest Ophthalmol Vis Sci. 2021 May 3;62(6):14. doi: 10.1167/iovs.62.6.14.
To investigate the characteristics of treatment-naïve nonexudative macular neovascularization (MNV) in age-related macular degeneration before the onset of exudation using swept-source optical coherence tomography angiography.
MNV area, choriocapillaris (CC) flow deficits (FDs), vessel area density (VAD), vessel skeleton density (VSD), retinal pigment epithelial detachment (PED) volume, mean choroidal thickness (MCT), and choroid vascularity index (CVI) measurements were assessed at two visits prior to exudation. We compared measurements made at the second visit and the rate of change between visits in eyes with and without exudation. The differences in these parameters between eyes with and without subsequent exudation were summarized with 95% confidence intervals (CIs).
Twenty-one eyes with nonexudative MNV were identified and followed. Nine eyes developed exudation, and 12 eyes did not develop exudation. Differences between these groups of eyes for all parameters tended to be small, and the 95% CIs largely ruled out any substantial differences. Overall, eyes with exudation had 24% smaller VAD, 20% smaller VSD, and 33% smaller PED volume measurements. No noteworthy differences were observed for MNV area, CC FDs, MCT, or CVI measurements.
The onset of exudation was correlated with lesions having less vascularity and smaller PED volume measurements, but measurements of MNV area, CC FDs, MCT, and CVI were not correlated with near-term exudation. Investigations are ongoing to further explore these and other anatomic changes as harbingers of near-term exudation.
利用扫频源光相干断层扫描血管造影术研究渗出性年龄相关性黄斑变性发生前未经治疗的非渗出性黄斑新生血管（MNV）的特征。
在出现渗出之前，通过两次就诊评估 MNV 面积、脉络膜毛细血管（CC）血流缺损（FD）、血管面积密度（VAD）、血管骨架密度（VSD）、视网膜色素上皮脱离（PED）体积、平均脉络膜厚度（MCT）和脉络膜血管指数（CVI）。比较发生渗出和未发生渗出的眼在第二次就诊时的测量值和就诊间的变化率。总结发生渗出和未发生渗出的眼之间这些参数的差异，并以 95%置信区间（CI）表示。
共发现并随访了 21 只未经治疗的非渗出性 MNV 眼。9 只眼发生渗出，12 只眼未发生渗出。这些组间的差异总体较小，95%CI 基本排除了任何实质性差异。总的来说，发生渗出的眼 VAD 小 24%，VSD 小 20%，PED 体积小 33%。MNV 面积、CC FD、MCT 或 CVI 测量值未见明显差异。
渗出的发生与血管密度较低和 PED 体积较小的病变有关，但 MNV 面积、CC FD、MCT 和 CVI 的测量值与近期渗出无关。正在进行进一步的研究以探索这些和其他解剖变化作为近期渗出的前兆。
