南海海绵 Halichondria sp. 的新甾醇

New sterols from the South China Sea sponges Halichondria sp.

机构信息

Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu GulfRim, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.

出版信息

Fitoterapia. 2021 Jul;152:104918. doi: 10.1016/j.fitote.2021.104918. Epub 2021 May 11.

DOI:10.1016/j.fitote.2021.104918

PMID:33984436

Abstract

A detailed chemical investigation of two specimen of South China Sea sponges Halichondria sp. (No. 19-XD-47 and No. 17-XD-87) have resulted in the isolation of three new sterols, namely, halichsterols A (1), B (2) and C (3), together with seven related known ones (4-10). Their structures were determined by extensive spectroscopic analysis and by comparison with the spectral data reported in the literature. In bioassay, compound 2 displayed significantly anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.

摘要

对南海海绵 Halichondria sp. 的两个标本（No. 19-XD-47 和 No. 17-XD-87）进行了详细的化学研究，分离得到了三种新的甾醇，分别为 halichosterols A（1）、B（2）和 C（3），以及七种相关的已知甾醇（4-10）。通过广泛的光谱分析以及与文献中报道的光谱数据进行比较，确定了它们的结构。在生物测定中，化合物 2 在脂多糖（LPS）刺激的 BV-2 小胶质细胞中表现出显著的抗炎活性。