Sager Gunes, Akgun Elife, Abuqbeitah Muhammed, Uslu Lebriz, Asa Sertac, Akgun Mehmet Yigit, Beytur Fatih, Baydili Kursat Nuri, Sager Sait
Kartal Lutfi Kirdar Training and Research Hospital, Department of Pediatric Neurology, Istanbul, Turkey.
Kirikkale Yuksek Ihtisas Hospital, Department of Nuclear Medicine, Kirikkale, Turkey.
Clin Neurol Neurosurg. 2021 Jul;206:106669. doi: 10.1016/j.clineuro.2021.106669. Epub 2021 Apr 27.
Standardized uptake values (SUVs) are important indexes for evaluating the accuracy of disease diagnoses achieved via fluoro-18 deoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). The purpose of this study is to describe normal cerebral FDG uptake in the pediatric population and compare SUVmax/mean results for brain images obtained from PET/CT and PET/MRI in neurologically healthy pediatric examinees.
This study included 20 patients who were < 18 years of age and were without intracranial malignancy and/or brain disorders. Patients underwent either PET/CT imaging (n = 10) or PET/MRI imaging (n = 10) after 70-80 min of F-18 FDG injection. The SUVmax and SUVmean for various brain regions were calculated and compared between sides and imaging modalities using with appropriate statistical tests.
The median SUVmax/SUVmean values of the right-sided frontal, parietal, temporal, and occipital lobes were 8.63/ 6.18, 8.85 / 6.97, 6.88 / 4.99, and 11.06 / 7.02 in PET/CT, respectively, and 11.45 / 8.59, 10.16 / 8.47, 8.82 / 6.6, and 11.71 / 8.25 in PET/MRI, respectively. The median SUVmax/SUVmean values of the left-sided frontal, parietal, temporal, and occipital lobes were 9.05 / 6.86, 8.03 / 6.62, 6.49 / 4.77, and 10.6 / 7.73 in PET/CT, respectively, and 10.7 / 8.16, 11.06 / 7.88, 8.13 / 6.09, and 10.96 / 9.22 in PET/MRI, respectively.
These results showed that there was no statistically significant difference in SUVs values between the two brain imaging modalities except from SUVmax value of left-sided parietal lobe and no asymmetric radiopharmaceutical uptake between the left and right brain regions or cerebellums in each modality, suggested that in brain imaging, PET/MRI can be used reliably instead of PET/CT.
标准化摄取值（SUVs）是评估通过氟代脱氧葡萄糖（F-18 FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）和正电子发射断层扫描/磁共振成像（PET/MRI）实现的疾病诊断准确性的重要指标。本研究的目的是描述儿科人群正常的脑氟代脱氧葡萄糖摄取情况，并比较在神经系统健康的儿科受检者中，从PET/CT和PET/MRI获得的脑部图像的SUVmax/平均值结果。
本研究纳入了20名年龄小于18岁且无颅内恶性肿瘤和/或脑部疾病的患者。在注射F-18 FDG 70 - 80分钟后，患者接受了PET/CT成像（n = 10）或PET/MRI成像（n = 10）。计算各个脑区的SUVmax和SUVmean，并使用适当的统计检验在两侧和成像方式之间进行比较。
PET/CT中，右侧额叶、顶叶、颞叶和枕叶的SUVmax/SUVmean中位数分别为8.63 / 6.18、8.85 / 6.97、6.88 / 4.99和11.06 / 7.02，PET/MRI中分别为11.45 / 8.59、10.16 / 8.47、8.82 / 6.6和11.71 / 8.25。PET/CT中，左侧额叶、顶叶、颞叶和枕叶的SUVmax/SUVmean中位数分别为9.05 / 6.86、8.03 / 6.62、6.49 / 4.77和10.6 / 7.73，PET/MRI中分别为10.7 / 8.16、11.06 / 7.88、8.13 / 6.09和10.96 / 9.22。
这些结果表明，除左侧顶叶的SUVmax值外，两种脑部成像方式的SUV值在统计学上无显著差异，且在每种成像方式中，左右脑区或小脑之间不存在不对称的放射性药物摄取，这表明在脑部成像中，PET/MRI可以可靠地替代PET/CT。
