International Research Center for Marine Biosciences at Shanghai Ocean University, Ministry of Science and Technology, Shanghai 201306, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China.
Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.
J Environ Sci (China). 2021 Jun;104:188-203. doi: 10.1016/j.jes.2020.11.013. Epub 2020 Dec 19.
Since the beginning of the 21st century, the increasing production and application of nano-TiO in consumer products have inevitably led to its release into aquatic systems and therefore caused the exposure of aquatic organisms, resulting in growing environmental concerns. However, the safety of nano-TiO in aquatic environments has not been systematically assessed, especially in coastal and estuary waters where a large number of filter-feeding animals live. Bivalves are considered around the world to be a unique target group for nanoparticle toxicity, and numerous studies have been conducted to test the toxic effects of nano-TiO on bivalves. The aim of this review was to systematically summarize and analyze published data concerning the toxicological effects of nano-TiO in bivalves. In particular, the toxicity of nano-TiO to the antioxidant system and cell physiology was subjected to meta-analysis to reveal the mechanism of the toxicological effects of nano-TiO and the factors affecting its toxicological effects. To reveal the cooperation, hot keywords and co-citations in this field, bibliometric analysis was conducted, and the results showed that the toxicological molecular mechanisms of nano-TiO and the combined effects of nano-TiO and other environmental factors are two major hot spots. Finally, some perspectives and insights were provided in this review for future research on nano-TiO toxicology in bivalves.
自 21 世纪初以来，纳米 TiO2 在消费产品中的产量和应用不断增加，不可避免地导致其释放到水生系统中，从而使水生生物暴露在其中，引发了越来越多的环境问题。然而，纳米 TiO2 在水生环境中的安全性尚未得到系统评估，特别是在沿海和河口水域，大量滤食性动物生活在这些水域。贝类被认为是全球范围内纳米颗粒毒性的独特靶标群体，已经进行了大量研究来测试纳米 TiO2 对贝类的毒性影响。本综述的目的是系统地总结和分析有关纳米 TiO2 对贝类的毒理学影响的已发表数据。特别是，对纳米 TiO2 对抗氧化系统和细胞生理学的毒性进行了荟萃分析，以揭示纳米 TiO2 毒理学效应的机制以及影响其毒理学效应的因素。为了揭示该领域的合作、热门关键词和共被引，进行了文献计量分析，结果表明，纳米 TiO2 的毒理学分子机制以及纳米 TiO2 与其他环境因素的联合效应是两个主要的热点。最后，本综述为贝类中纳米 TiO2 毒理学的未来研究提供了一些观点和见解。
