Wang Ting, Liu Wei
Department F.-A. Forel for Environmental and Aquatic Sciences, Faculty of Sciences, Earth and Environment Sciences, University of Geneva Uni Carl Vogt, 66 Blvd Carl-Vogt CH 1211 Geneva Switzerland
Environ Sci Nano. 2022 May 6;9(7):2237-2263. doi: 10.1039/d2en00052k. eCollection 2022 Jul 14.
The increasing use of metal oxide-based nanoparticles (MNPs) and their release into the environment cast concerns about their environmental impacts. Massive efforts have been focused on environmental behaviours and ecotoxicities to figure out the potential threats posed by MNPs. This review systematically summarises and re-analyses published data about the MNP interactions and transformation processes in freshwater and the toxicological effects of MNPs on invertebrates. A case study was conducted through meta-analysis to examine the impacts of silver nanoparticle exposure to freshwater invertebrates. The conclusions categorized the current understanding of the outcome and ecotoxicity of MNPs in freshwater. The adverse outcome pathway (AOP) is recommended for environmental risk assessment as it provides a rapid and accurate risk assessment of an increasing number of novel compounds consuming fewer resources and animal tests. Invertebrates contribute significantly towards developing robust AOPs thanks to a shorter life cycle, allowing chronic and complete life cycle toxicity tests.
基于金属氧化物的纳米颗粒（MNPs）的使用日益增加，且它们释放到环境中引发了人们对其环境影响的担忧。大量努力集中在环境行为和生态毒性方面，以弄清楚MNPs带来的潜在威胁。本综述系统地总结并重新分析了已发表的关于MNPs在淡水中的相互作用和转化过程以及MNPs对无脊椎动物的毒理学影响的数据。通过荟萃分析进行了一项案例研究，以检验银纳米颗粒暴露对淡水无脊椎动物的影响。这些结论对目前对MNPs在淡水中的结果和生态毒性的理解进行了分类。推荐使用不良结局途径（AOP）进行环境风险评估，因为它能以较少的资源消耗和动物试验，对越来越多的新型化合物进行快速准确的风险评估。由于生命周期较短，无脊椎动物对制定稳健的AOP有很大贡献，这使得能够进行慢性和完整生命周期的毒性试验。
