Maniar Y M, Peck K K, Jenabi M, Gene M, Holodny A I
From the Department of Radiology (Y.M.M., K.K.P., M.J., M.G., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York.
From the Department of Radiology (Y.M.M., K.K.P., M.J., M.G., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York
AJNR Am J Neuroradiol. 2021 Aug;42(8):1505-1512. doi: 10.3174/ajnr.A7138. Epub 2021 May 13.
The default mode network normally decreases in activity during externally directed tasks. Although default mode network connectivity is disrupted in numerous brain pathologies, default mode network deactivation has not been studied in patients with brain tumors. We investigated default mode network deactivation with language task-based fMRI by measuring the anticorrelation of a critical default mode network node, the posterior cingulate cortex, in patients with gliomas and controls; furthermore, we examined default mode network functional connectivity in these patients with task-based and resting-state fMRI.
In 10 healthy controls and 30 patients with gliomas, the posterior cingulate cortex was identified on task-based fMRI and was used as an ROI to create connectivity maps from task-based and resting-state fMRI data. We compared the average correlation in each default mode network region between patients and controls for each correlation map and stratified patients by tumor location, hemisphere, and grade.
Patients with gliomas ( = .001) and, in particular, patients with tumors near the posterior default mode network ( < .001) showed less posterior cingulate cortex anticorrelation in task-based fMRI than controls. Patients with both left- and right-hemisphere tumors, as well as those with grade IV tumors, showed significantly lower posterior cingulate cortex anticorrelation than controls ( = .02, .03, and <.001, respectively). Functional connectivity in each default mode network region was not significantly different between task-based and resting-state maps.
Task-based fMRI showed impaired deactivation of the default mode network in patients with gliomas. The functional connectivity of the default mode network in both task-based and resting-state fMRI in patients with gliomas using the posterior cingulate cortex identified in task-based fMRI as an ROI for seed-based correlation analysis has strong overlap.
默认模式网络在外部导向任务期间通常活动减少。尽管默认模式网络连接性在多种脑部病变中受到破坏，但尚未在脑肿瘤患者中研究默认模式网络失活情况。我们通过测量关键默认模式网络节点——后扣带回皮质的反相关性，利用基于语言任务的功能磁共振成像（fMRI）研究胶质瘤患者和对照组的默认模式网络失活情况；此外，我们还使用基于任务和静息态的fMRI检查了这些患者的默认模式网络功能连接性。
在10名健康对照者和30名胶质瘤患者中，通过基于任务的fMRI识别出后扣带回皮质，并将其用作感兴趣区域（ROI），以从基于任务和静息态的fMRI数据创建连接图。我们比较了每个相关图中患者和对照者在每个默认模式网络区域的平均相关性，并按肿瘤位置、半球和分级对患者进行分层。
胶质瘤患者（P = 0.001），特别是后默认模式网络附近有肿瘤的患者（P < 0.001），在基于任务的fMRI中显示后扣带回皮质的反相关性低于对照组。左半球和右半球肿瘤患者以及IV级肿瘤患者的后扣带回皮质反相关性均显著低于对照组（分别为P = 0.02、0.03和P < 0.001）。基于任务和静息态图之间，每个默认模式网络区域的功能连接性无显著差异。
基于任务的fMRI显示胶质瘤患者默认模式网络失活受损。使用基于任务的fMRI中识别出的后扣带回皮质作为基于种子的相关性分析的ROI，胶质瘤患者在基于任务和静息态fMRI中的默认模式网络功能连接性有很强的重叠。
