Department of Psychiatry, Cheongju Hospital, Cheongju, South Korea.
Department of Psychiatry, Silverheals Hospital, Namyangju, South Korea.
Sci Rep. 2021 May 13;11(1):10174. doi: 10.1038/s41598-021-89521-9.
Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer's disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14) sat about 60 cm away from a small (136 × 73 × 16 mm) LED light box for 1 h each morning for 2 weeks. The control group (n = 11) wore dark, blue-attenuating sunglasses during the 1 h exposures. The morning light started 9-10 h after each individual's dim light melatonin onset (DLMO). Assessments were done at baseline (T0), immediate post-treatment (T1), and 4 weeks after the end of the 2 weeks of LT (T2). Sleep was measured by actigraphy. Blue-enriched LT had a significantly better effect on the Pittsburgh Sleep Quality Index at T2 compared to blue-attenuated LT, and a trend of better effectiveness on total sleep time at T2. There was a significant increase in Mini-Mental State Examination score at T2 after blue-enriched LT than that at T0. Our findings suggest that morning blue-enriched LT has a benefit in improving sleep and cognitive function in AD patients.
关于光疗（LT）在阿尔茨海默病（AD）患者中的有效性，已有相互矛盾的结果报道。我们研究了富含蓝光的 LT 对轻度和中度 AD 患者睡眠、认知、情绪和行为的影响。治疗组（n=14）每天早上坐在离一个小的（136×73×16 毫米）LED 灯箱约 60 厘米处，接受 1 小时的光照，持续 2 周。对照组（n=11）在 1 小时的暴露期间佩戴深色、蓝光衰减的太阳镜。早晨的光在每个人的褪黑素开始时间（DLMO）后 9-10 小时开始。评估在基线（T0）、治疗后即刻（T1）和 2 周 LT 结束后 4 周（T2）进行。睡眠通过活动记录仪进行测量。与蓝光衰减 LT 相比，富含蓝光的 LT 在 T2 时对匹兹堡睡眠质量指数的影响明显更好，在 T2 时总睡眠时间的效果也有改善的趋势。与 T0 相比，在接受富含蓝光的 LT 治疗后，简易精神状态检查表的分数在 T2 时显著增加。我们的发现表明，早晨富含蓝光的 LT 可改善 AD 患者的睡眠和认知功能。
