Ghosh Mousumi, Palaniswamy Hari Prakash, G Nishitha, Joylin Stelyna, T S Shwetha, Sanjana M, Radhika R P, Theruveethi Nagarajan
Department of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, 576104, India.
Department of Optometry, Dr B.C.Roy Academy of Professional Courses, Durgapur, West Bengal, India.
Neurobiol Sleep Circadian Rhythms. 2025 Apr 17;18:100119. doi: 10.1016/j.nbscr.2025.100119. eCollection 2025 May.
White light-emitting diodes WLEDs) can affect cognition and working memory. Blue light-blocking lenses (BBL) may help alleviate this. We aim to study the relationship between WLED and the ameliorative effect of BBL. We included 15 healthy participants based on the PSQI and Mini-Cog™ screening. The eligible participants underwent a baseline recording of event-related potential (ERP) of P300 using electroencephalography (EEG) while performing a 2-back task, followed by exposure to WLED (600 lux) that was given (45° with 80 cm apart from the participant's eye plane) for 30 min. A similar protocol was maintained when BBL was worn with WLED exposure. The participants' mean PSQI and Mini-Cog™ scores (n = 15) were 3 and 5, respectively. The behavioral functioning of participants using a 2-back task revealed enhancement in working memory cognition by fastening the response time (ms) from base to post-WLED to post-WLED + BBL (p < 0.001). Still, no significant difference (p > 0.05) in accuracy (%) was observed. The learning effect in the control group using a 2-back task revealed no statistically significant difference (p > 0.05) in both accuracy (%) and response time (ms). Additionally, no significant change (p > 0.05) was found within the three light groups in latency (ms) and amplitude (μV) at the P300 region of ERP in the prefrontal cortex. The existing results found that domestic WLED exposure significantly leads to a faster response time in working memory performance in the prefrontal cortex, thus remaining alert. BBL is not protective in the nonvisual senses when exposed to WLED for 30 min.
白光发光二极管（WLED）会影响认知和工作记忆。蓝光阻挡镜片（BBL）可能有助于缓解这一情况。我们旨在研究WLED与BBL的改善效果之间的关系。我们基于匹兹堡睡眠质量指数（PSQI）和简易认知筛查量表（Mini-Cog™）筛选出15名健康参与者。符合条件的参与者在执行2-back任务时，使用脑电图（EEG）对P300的事件相关电位（ERP）进行基线记录，随后暴露于WLED（600勒克斯）下（与参与者眼睛平面成45°角，距离80厘米）30分钟。当佩戴BBL并暴露于WLED时，保持类似的方案。参与者的平均PSQI和Mini-Cog™分数（n = 15）分别为3分和5分。使用2-back任务的参与者的行为功能显示，通过加快从基线到WLED后以及WLED + BBL后的反应时间（毫秒），工作记忆认知得到增强（p < 0.001）。然而，在准确率（%）方面未观察到显著差异（p > 0.05）。对照组使用2-back任务的学习效果显示，在准确率（%）和反应时间（毫秒）方面均无统计学显著差异（p > 0.05）。此外，在前额叶皮层ERP的P300区域，三个光照组在潜伏期（毫秒）和波幅（微伏）方面均未发现显著变化（p > 0.05）。现有结果发现，国内WLED暴露显著导致前额叶皮层工作记忆表现的反应时间更快，从而保持警觉。当暴露于WLED 30分钟时，BBL在非视觉感官方面没有保护作用。
