Wiles Rebecca J, Molander Gary A
Department of Chemistry, University of Pennsylvania, 231 S. 34 St. Philadelphia, PA 19104.
Isr J Chem. 2020 Mar;60(3-4):281-293. doi: 10.1002/ijch.201900166. Epub 2020 Feb 18.
Radical/Polar Crossover (RPC) chemistry is a rapidly growing subset of photoredox catalysis that is characterized by transformations featuring both radical and ionic modes of reactivity. Net-neutral RPC is particularly interesting in that both the single-electron oxidation and reduction steps occur through interaction with the photocatalyst, thus precluding the need for exogenous oxidants or reductants. As such, these transformations facilitate rapid incorporation of molecular complexity while maintaining mild reaction conditions. This review covers recent advances in photoredox-mediated net-neutral RPC synthetic methods, with a particular emphasis on C-C bond-forming reactions.
自由基/极性交叉（RPC）化学是光氧化还原催化中一个快速发展的分支，其特点是反应同时具有自由基和离子反应模式。净中性RPC尤其引人关注，因为单电子氧化和还原步骤均通过与光催化剂相互作用发生，从而无需外源氧化剂或还原剂。因此，这些反应在保持温和反应条件的同时，能够快速引入分子复杂性。本综述涵盖了光氧化还原介导的净中性RPC合成方法的最新进展，特别着重于碳-碳键形成反应。
