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还原自由基-极性交叉：现代自由基反应中的传统亲电试剂。

Reductive radical-polar crossover: traditional electrophiles in modern radical reactions.

作者信息

Pitzer Lena, Schwarz J Luca, Glorius Frank

机构信息

Organisch-Chemisches Institut , Westfälische Wilhelms-Universität Münster , Corrensstraße 40 , 48149 Münster , Germany . Email:

出版信息

Chem Sci. 2019 Aug 16;10(36):8285-8291. doi: 10.1039/c9sc03359a. eCollection 2019 Sep 28.

DOI:10.1039/c9sc03359a
PMID:32055300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7003961/
Abstract

The concept of reductive radical-polar crossover (RRPCO) reactions has recently emerged as a valuable and powerful tool to overcome limitations of both radical and traditional polar chemistry. Especially in case of additions to carbonyl compounds, the synergy of radical and polar pathways is of great advantage since it enables the use of traditional carbonyl electrophiles in radical reactions. The most recent and synthetically important transformations following this line are summarised in the first part of this review. The second part deals with transformations, in which the concept of RRPCO promotes the usage of alkyl halides as electrophiles in radical reactions.

摘要

还原自由基-极性交叉（RRPCO）反应的概念最近已成为一种有价值且强大的工具，用于克服自由基化学和传统极性化学的局限性。特别是在羰基化合物加成反应中，自由基和极性反应途径的协同作用具有很大优势，因为它能够在自由基反应中使用传统的羰基亲电试剂。本综述的第一部分总结了遵循这一思路的最新且具有合成重要性的转化反应。第二部分讨论了RRPCO概念促进卤代烃在自由基反应中作为亲电试剂使用的转化反应。

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