2型糖尿病患者致命和非致命心血管事件的预后因素：肾功能生物标志物的作用
Prognostic Factors of Fatal and Nonfatal Cardiovascular Events in Patients With Type 2 Diabetes: The Role of Renal Function Biomarkers.
作者信息
Roumeliotis Stefanos, Liakopoulos Vassilios, Roumeliotis Athanasios, Stamou Aikaterini, Panagoutsos Stylianos, D'Arrigo Graziella, Tripepi Giovanni
机构信息
Division of Nephrology and Hypertension, 1 Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Institute of Clinical Physiology (IFC-CNR), Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy.
出版信息
Clin Diabetes. 2021 Apr;39(2):188-196. doi: 10.2337/cd20-0067.
Abstract
In this study, 158 patients with different degrees of renal function were followed for 7 years to assess the prognostic value of various risk factors, including carotid intima-media thickness (cIMT) and biomarkers of renal function, for incident cardiovascular morbidity and mortality in patients with type 2 diabetes. The investigators found that estimated glomerular filtration rate, albuminuria, and history of cardiovascular disease (CVD) can be used for prognosis of CVD, whereas cIMT adds little to the accuracy of this prediction.
摘要
在本研究中，对158例不同肾功能程度的患者进行了7年随访，以评估各种危险因素（包括颈动脉内膜中层厚度（cIMT）和肾功能生物标志物）对2型糖尿病患者发生心血管疾病的发病率和死亡率的预后价值。研究人员发现，估算肾小球滤过率、蛋白尿和心血管疾病（CVD）病史可用于CVD的预后评估，而cIMT对这一预测准确性的提升作用不大。
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