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创伤后癫痫:深入探讨发病机制。

Post-Traumatic Seizures: A Deep-Dive Into Pathogenesis.

作者信息

Anwer Fatima, Oliveri Federico, Kakargias Fotios, Panday Priyanka, Arcia Franchini Ana P, Iskander Beshoy, Hamid Pousette

机构信息

Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Cardiology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

出版信息

Cureus. 2021 Apr 10;13(4):e14395. doi: 10.7759/cureus.14395.

Abstract

Post-traumatic seizures (PTS) have become an emerging challenge for neurologists worldwide with the rise of brain injuries. Trauma can lead to various outcomes, ranging from naive spasms to debilitating post-traumatic epilepsy (PTE). In this article, we will explore the pathogenesis of convulsions following a concussion. We will look at multiple studies to explain the various structural, metabolic, and inflammatory changes leading to seizures. Additionally, we will explore the association between severity and location of injury and PTE. PTE's pathophysiology is not entirely implicit, and we are still in the dark as to which anti-epileptic drugs will be useful in circumventing these attacks. The purpose of this narrative review is to explain the post-traumatic brain changes in detail so that such attacks can be either thwarted or treated more resourcefully in the future.

摘要

随着脑损伤的增加,创伤后癫痫发作(PTS)已成为全球神经科医生面临的一个新挑战。创伤可导致各种后果,从单纯的痉挛到使人衰弱的创伤后癫痫(PTE)。在本文中,我们将探讨脑震荡后惊厥的发病机制。我们将查看多项研究,以解释导致癫痫发作的各种结构、代谢和炎症变化。此外,我们将探讨损伤的严重程度和部位与PTE之间的关联。PTE的病理生理学并不完全清楚,我们仍不清楚哪种抗癫痫药物对预防这些发作有用。这篇叙述性综述的目的是详细解释创伤后脑的变化,以便将来能够更有效地预防或治疗此类发作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6ae/8110294/57e2f65f1959/cureus-0013-00000014395-i01.jpg

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