Da Cunha Teresa, Mago Sheena, Bath Roopjeet K
Internal Medicine, University of Connecticut Health, Farmington, USA.
Gastroenterology, Allegheny Health Network, Pittsburgh, USA.
Cureus. 2022 Apr 28;14(4):e24552. doi: 10.7759/cureus.24552. eCollection 2022 Apr.
Infection with Epstein-Barr virus (EBV) is common and associated with a high seroprevalence. It is often asymptomatic, but infectious mononucleosis (IM) is the clinical hallmark of this disease especially among teens. Hepatic involvement during primary EBV infection often results in mild self-resolving elevation of liver enzymes, typically in association with IM. However, cholestatic hepatitis might sporadically occur. EBV reactivation is rare, especially among immunocompetent patients. Moreover, reactivation of EBV causing isolated cholestatic hepatitis is extremely rare and only reported in patients who are immunocompromised. Here we present a unique case of EBV reactivation causing cholestatic hepatitis in an otherwise healthy and immunocompetent female and we review the epidemiology, clinical presentation, diagnosis, and treatment of EBV induced cholestatic hepatitis.
感染爱泼斯坦-巴尔病毒（EBV）很常见，且血清阳性率很高。它通常无症状，但传染性单核细胞增多症（IM）是这种疾病的临床标志，尤其是在青少年中。原发性EBV感染期间肝脏受累通常会导致肝酶轻度自限性升高，通常与IM相关。然而，胆汁淤积性肝炎可能偶尔发生。EBV再激活很少见，尤其是在免疫功能正常的患者中。此外，EBV再激活导致孤立性胆汁淤积性肝炎极为罕见，仅在免疫功能低下的患者中报道。在此，我们报告一例独特的病例，一名原本健康且免疫功能正常的女性因EBV再激活导致胆汁淤积性肝炎，我们还回顾了EBV诱导的胆汁淤积性肝炎的流行病学、临床表现、诊断和治疗。
