Ye Xinjian, Gu Ying, Bai Yijing, Xia Siqi, Zhang Yujia, Lou Yuwei, Zhu Yuchi, Dai Yuwei, Tsoi James Kit-Hon, Wang Shuhua
School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, China.
Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong.
Front Bioeng Biotechnol. 2021 Apr 27;9:626892. doi: 10.3389/fbioe.2021.626892. eCollection 2021.
Being as a non-pharmacological medical intervention, low-magnitude high-frequency vibration (LMHFV) has shown a positive effect on bone induction and remodeling for various muscle diseases in animal studies, among which dental implants osteointegration were reported to be improved as well. However, whether LMHFV can be clinically used in dental implant is still unknown. In this study, efficacy, parameters and side effects of LMHFV were analyzed via data before 15th July 2020, collecting from MEDLINE/PubMed, Embase, Ovid and Cochrane Library databases. In the screened 1,742 abstracts and 45 articles, 15 animal studies involving 972 implants were included. SYRCLE's tool was performed to assess the possible risk of bias for each study. The GRADE approach was applied to evaluate the quality of evidence. Random effects meta-analysis detected statistically significant in total BIC ( < 0.0001) and BV/TV ( = 0.001) upon loading LMHFV on implants. To conclude, LMHFV played an active role on BIC and BV/TV data according to the GRADE analysis results (medium and low quality of evidence). This might illustrate LMHFV to be a worthy way in improving osseointegration clinically, especially for osteoporosis. https://www.crd.york.ac.uk/PROSPERO, identifier: NCT02612389.
作为一种非药物性医学干预措施，低强度高频振动（LMHFV）在动物研究中已显示出对各种肌肉疾病的骨诱导和重塑具有积极作用，其中据报道牙种植体的骨整合也得到了改善。然而，LMHFV是否可临床应用于牙种植体仍不清楚。在本研究中，通过收集2020年7月15日前来自MEDLINE/PubMed、Embase、Ovid和Cochrane图书馆数据库的数据，分析了LMHFV的疗效、参数和副作用。在筛选出的1742篇摘要和45篇文章中，纳入了15项涉及972颗种植体的动物研究。使用SYRCLE工具评估每项研究可能存在的偏倚风险。采用GRADE方法评估证据质量。随机效应荟萃分析发现，在种植体上加载LMHFV后，总骨-种植体接触率（BIC，<0.0001）和骨体积分数/组织体积分数（BV/TV，=0.001）具有统计学意义。总之，根据GRADE分析结果（证据质量为中等和低等），LMHFV对BIC和BV/TV数据发挥了积极作用。这可能说明LMHFV在临床上是一种改善骨整合的有价值方法，尤其是对于骨质疏松症。https://www.crd.york.ac.uk/PROSPERO，标识符：NCT02612389。
