Chapkin R S, Somers S D, Schumacher L, Erickson K L
Department of Human Anatomy, School of Medicine, University of California, Davis 95616.
Lipids. 1988 Apr;23(4):380-3. doi: 10.1007/BF02537356.
The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P less than 0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P less than 0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.
在给小鼠喂食特定食用油四周后，其腹膜巨噬细胞磷脂的多不饱和脂肪酸（PUFA）组成在体内发生了显著变化。喂食鱼油（含有20:5n-3和22:6n-3）显著增加了巨噬细胞中的20:5n-3、22:5n-3和22:6n-3（P<0.05），而相对于喂食红花油（含有18:2n-6）和氢化椰子油（含有12:0）的动物，喂食琉璃苣油（含有18:2n-6和18:3n-6）增加了巨噬细胞中20:3n-6/20:4n-6的比例（P<0.05）。将巨噬细胞磷脂PUFA谱与肝脏、肺和脾脏的谱进行了比较。讨论了PUFA变化的意义。
