Physiological Characteristics and Anti-Diabetic Effect of KI62.

The purpose of this study is to examine the physiological characteristics and anti-diabetic effects of KI62. The α-amylase and α-glucosidase inhibitory activity of KI62 was 94.86±3.30% and 98.59±0.52%, respectively. In MRS broth containing 3% maltodextrin inoculated by KI62, the amounts of short chain fatty acids (SCFA) were propionic acid 18.05±1.85 mg/kg, acetic acid 1.12±0.07 g/100 mL, and butyric acid 2.19±0.061 g/kg, and those of medium chain fatty acids (MCFA) were C8 0.262±0.031 mg/kg, C10 0.279±0.021 mg/kg, and C12 0.203±0.009 mg/kg. Compared to sixteen antibiotics, KI62 had the highest sensitivity to penicillin-G and rifampicin, as well as the highest resistance to vancomycin and ampicillin. The strain also showed higher leucine arylamidase and valine arylamidase activities than other enzyme activities, but it did not produce β-glucuronidase which is carcinogenic enzymes. The survival rate of KI62 in 0.3% bile was 91.67%. Moreover, the strain showed a 98.63% survival rate in pH 2.0. KI62 exhibits resistance to , Typhimurium, , and at rates of 29.41%, 38.10%, 51.72%, and 50.47%, respectively. (23.31%) showed a similar adhesion ability to GG, the positive control (24.49%). These results show that KI62 has possibility as a probiotic with anti-diabetic effects.