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新型抗原——杜氏利什曼原虫的Otubain 半胱氨酸肽酶，用于内脏利什曼病的血清学诊断和治疗反应监测。

A Novel Antigen, Otubain Cysteine Peptidase of Leishmania donovani, for the Serodiagnosis of Visceral Leishmaniasis and for Monitoring Treatment Response.

机构信息

Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India.

Rajendra Memorial Research Institute of Medical Sciences, Patna, India.

出版信息

Clin Infect Dis. 2021 Oct 5;73(7):1281-1283. doi: 10.1093/cid/ciab435.

DOI:10.1093/cid/ciab435
PMID:33987660
Abstract

Tests for visceral leishmaniasis (VL) are not uniformly effective for all endemic regions. In a serological assay, a novel antigen, otubain cysteine peptidase, compared with rK39, showed comparable sensitivity with Indian VL serum samples and prominently increased sensitivity with Brazilian samples, as well as improved monitoring of the treatment response.

摘要

内脏利什曼病（VL）的检测方法并非对所有流行地区都普遍有效。在血清学检测中，一种新型抗原——泛素胱天蛋白酶，与 rK39 相比，对印度 VL 血清样本具有相当的敏感性，并显著提高了对巴西样本的敏感性，同时也改善了治疗效果的监测。

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