Centre of Excellence in Sustainable Aquaculture and Aquatic Animal Health Management (CAAHM), Department of Aquaculture, Kerala University of Fisheries and Ocean Studies, Panangad, Kochi, 682506, Kerala, India.
National Centre for Aquatic Animal Health, Cochin University of Science and Technology, Kochi, 682016, Kerala, India.
Fish Physiol Biochem. 2021 Aug;47(4):1011-1031. doi: 10.1007/s10695-021-00961-6. Epub 2021 May 14.
The insulin-like growth factor signalling system comprises insulin-like growth factors, insulin-like growth factor receptors and insulin-like growth factor-binding proteins. Along with the growth hormones, insulin-like growth factor signalling is very pivotal in the growth and development of all vertebrates. In fishes, insulin-like growth factors play an important role in osmoregulation, besides the neuroendocrine regulation of growth. Insulin-like growth factor concentration in plasma can assess the growth in fishes and shellfishes and therefore widely applied in nutritional research as an indicator to evaluate the performance of selected nutrients. The present review summarizes the role of insulin-like growth factor signalling in fishes and shellfishes, its significance in aquaculture and in evaluating growth, reproduction and development, and discusses the utility of this system as biomarkers for early indication of growth in aquaculture.
胰岛素样生长因子信号系统包括胰岛素样生长因子、胰岛素样生长因子受体和胰岛素样生长因子结合蛋白。与生长激素一样，胰岛素样生长因子信号在所有脊椎动物的生长和发育中起着至关重要的作用。在鱼类中，胰岛素样生长因子除了对生长的神经内分泌调节外，在渗透压调节中也起着重要作用。血浆中胰岛素样生长因子的浓度可以评估鱼类和贝类的生长，因此广泛应用于营养研究中，作为评估所选营养素性能的指标。本综述总结了胰岛素样生长因子信号在鱼类和贝类中的作用，及其在水产养殖中评估生长、繁殖和发育中的意义，并讨论了该系统作为水产养殖中生长早期指标的生物标志物的应用。
