Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
State Key Laboratory of Analytical Chemistry and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, China.
Adv Mater. 2021 Jul;33(26):e2100629. doi: 10.1002/adma.202100629. Epub 2021 May 13.
Engineering of efficient and safe materials remains a challenge for cancer therapy. Here, the lipid droplet, an organelle in adipocytes, is demonstrated to be a controllable and biocompatible vehicle to deliver anticancer drugs. It is validated that isolated lipid droplets maintain their key physiological functions to interact with other organelles and augment the therapeutic effect of cancer photodynamic therapy by encapsulation with a lipid-conjugated photosensitizer (Pyrolipid) through a variety of pathways, including generation of reactive oxygen species (ROS); lipid peroxidation; and endoplasmic reticulum (ER) stress. As such, the IC value of Pyrolipid is reduced by 6.0-fold when loaded into the lipid droplet. Of note, in vivo results demonstrate that engineered lipid droplets induce significant inhibition of tumor growth with minimal side effects.
用于癌症治疗的高效且安全材料的研发仍是一项挑战。在这里，脂肪滴——脂肪细胞中的一种细胞器，被证明是一种可控且生物相容的载体，可用于递送抗癌药物。研究结果表明，通过用脂质偶联的光敏剂（Pyrolipid）包封，分离的脂肪滴可通过多种途径（包括生成活性氧（ROS）、脂质过氧化和内质网（ER）应激）保持其与其他细胞器相互作用的关键生理功能，并增强癌症光动力治疗的疗效。因此，当 Pyrolipid 被载入脂肪滴时，其 IC 值降低了 6.0 倍。值得注意的是，体内结果表明，工程化的脂肪滴可在最小副作用的情况下显著抑制肿瘤生长。
